Wegovy (semaglutide, 2.4mg): Qhov hnyav poob qis tom qab 2 xyoos ntawm kev kho mob!

Novo Nordisk tsis ntev los no tau tshaj tawm cov txiaj ntsig ntawm Phase 3b kev sim tshuaj (STEP 5) ntawm cov tshuaj rog rog tshiab Wegovy (semaglutide, 2.4 mg subcutaneous txhaj) ntawm 2021 American Obesity Week (ObesityWeek® 2021) lub rooj sib tham. Kev sim tau ua nyob rau hauv 304 cov neeg laus uas rog rog (BMI≥30kg / m2) lossis rog dhau (BMI≥27kg / m2), thiab ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm Wegovy thiab placebo hauv kev kho mob rog lossis rog, ob qho tib si tau ua ke nrog kev noj zaub mov tsawg thiab ua kom lub cev muaj zog, kev kho mob kav 104 lub lis piam (2 xyoos). Cov ntaub ntawv qhia tau hais tias cov neeg laus cov neeg mob kho nrog Wegovy tau ua tiav qhov hnyav thiab hnyav poob thaum lub sijhawm kawm 2 xyoos.

Tshwj xeeb, piv nrog cov pab pawg placebo, cov neeg mob hauv pab pawg kho mob Wegovy poob qis heev los ntawm lub hauv paus mus rau lub lim tiam 104 (-15.2% vs -2.6%; kev kho mob sib txawv: -12.6% [95% CI: -15.3, -9.8] ; P [ GG] lt; 0.0001). Tsis tas li ntawd, txoj kev tshawb fawb kuj tau pom tias piv nrog cov placebo pab pawg, qhov feem pua ​​​​ntawm cov neeg mob hauv Wegovy kev kho mob poob ≥5% (77.1% vs 34.4%; p< 0.0001).="" raws="" li="" ntau="" qhov="" kev="" sim="" 68-lub="" lim="" tiam="" dhau="" los,="" wegovy'="" feem="" ntau="" tshaj="" tawm="" cov="" xwm="" txheej="" tsis="" zoo="" yog="" xeev="" siab,="" raws="" plab,="" ntuav,="" cem="" quav,="" thiab="" mob="" plab.="" hauv="" kauj="" ruam="" 5,="" qhov="" kev="" nyab="" xeeb="" ntawm="" wegovy="" tau="" ua="" raws="" li="" kauj="" ruam="" 3a="" kev="" sim="" dhau="" los;="" 5.9%="" ntawm="" pab="" pawg="" kho="" mob="" wegovy="" thiab="" 4.6%="" ntawm="" pawg="" placebo="" tau="" tso="" tseg="" kev="" kho="" mob="" tas="" li="" vim="" muaj="" xwm="" txheej="" tsis="">

Dr. W. Timothy Garvey, tus xibfwb thiab tus thawj saib xyuas ntawm Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv ntawm University of Alabama ntawm Birmingham, tau hais tias: “Cov neeg mob rog rog tau sim qhov nruab nrab ntawm 7 qhov kev poob phaus ua ntej nrhiav kev kho mob. Txawm li cas los xij, thaum lawv poob phaus, lawv zoo li rov zoo dua. Tias yog vim li cas Txoj kev uas tuaj yeem pab cov neeg mob rog rog poob phaus thiab nyob deb ntawm kev rog yog qhov tseem ceeb. Cov txiaj ntsig ntawm STEP 5 mus sib hais qhia tias cov neeg laus rog rog tuaj yeem poob phaus thiab tswj kev poob phaus thaum 2 xyoos ntawm kev kho Wegovy. Qhov no yuav pab tau peb zoo dua kho thiab tswj kev rog rog raws li ib tug mob ntev."

Doug Langa, Thawj Tswj Hwm ntawm Novo Nordisk thiab Tus Lwm Thawj Coj ntawm North America Kev Ua Haujlwm, tau hais tias:" Kev rog dhau yog ib yam kab mob ntev uas cuam tshuam nrog yam tsawg kawg 60 lwm yam mob thiab txo lub neej expectancy. Wegovy' qhov kev pom zoo rau kev teev npe muab lub sijhawm tseem ceeb rau peb los ntawm kev lag luam. Txhawb kom muaj txiaj ntsig kev hloov pauv hauv kev kho mob rog rog."

Kev rog rog yog ib yam kab mob uas yuav tsum tau kho mus ntev. Nws yog txuam nrog ntau yam mob hnyav thiab txo lub neej expectancy. Muaj ntau yam teeb meem kev rog rog, suav nrog hom 2 mob ntshav qab zib, kab mob plawv, obstructive pw tsaug zog apnea, kab mob raum ntev, tsis haus dej cawv fatty siab, thiab mob qog noj ntshav.

Lub Rau Hli Ntuj xyoo no, US FDA tau pom zoo Wegovy (semaglutide, 2.4 mg subcutaneous txhaj), uas yog ib zaug ib lub lim tiam glucagon-zoo li peptide-1 (GLP-1) analogue rau kev tswj qhov hnyav mus ntev. Tshwj xeeb tshaj yog haum rau: raws li ib tug pab txhais tau tias ntawm cov uas tsis muaj-calorie zaub mov thiab ntxiv dag zog rau kev ua si, rau kev kho mob ntawm cov neeg laus cov neeg mob rog rog (BMI ≥ 30kg / m2) los yog rog rog (BMI ≥ 27 kg / m2) nrog rau yam tsawg kawg yog ib tug hnyav hnyav. kev tsis sib haum xeeb. Hais txog kev saib xyuas, Novo Nordisk tau xa Daim Ntawv Pov Thawj Saib Xyuas Tseem Ceeb (PRV) txhawm rau txhawm rau txhawm rau txheeb xyuas qhov nrawm.

Nws tsim nyog hais tias Wegovy yog thawj zaug thiab tsuas yog ib lub lim tiam GLP-1 receptor agonist pom zoo rau kev tswj qhov hnyav ntawm cov neeg mob rog. Qhov kev pom zoo yog nyob ntawm cov txiaj ntsig ntawm STEP 3a qhov kev sim tshuaj ntsuam xyuas. Txoj haujlwm no koom nrog ntau dua 4,500 tus neeg mob rog rog lossis rog rog. Hauv kev sim tshuaj nrog cov neeg uas tsis muaj ntshav qab zib hom 2, cov neeg mob rog rog tau kho nrog Wegovy poob qhov nruab nrab ntawm 17-18% qhov hnyav hauv 68 lub lis piam. Thoob plaws hauv txoj haujlwm, Wegovy muaj kev nyab xeeb thiab zam tau zoo, thiab cov tshuaj tiv thaiv kab mob feem ntau yog kev ua rau plab hnyuv.

Hauv Tebchaws Meskas, Wegovy' qhov kev pom zoo rau kev ua lag luam tau ua rau muaj kev cia siab zoo rau cov neeg rog rog. Txawm hais tias qhov kev siv zog zoo tshaj plaws kom poob phaus, ntau tus neeg rog rog tseem pom tias nws nyuaj rau kev ua tiav thiab tswj kom poob phaus vim muaj kev cuam tshuam ntawm lub cev uas tsim nyog rau kev rov qab los. Raws li cov khoom poob phaus nrog kev ua tau zoo uas tsis tau pom dua hauv kev poob phaus, Wegovy cim lub sijhawm tshiab hauv kev kho mob rog.

Semaglutide yog tib neeg glucagon-zoo li peptide-1 (GLP-1) analogue, uas txhawb cov insulin secretion thiab inhibits glucagon secretion los ntawm cov piam thaj concentration-dependent mechanism, uas tuaj yeem txhim kho cov ntshav qabzib ntau ntawm cov neeg mob ntshav qab zib hom 2, thiab. kev pheej hmoo ntawm hypoglycemia yog tsawg. Ntxiv rau,semaglutidetuaj yeem ua rau kom poob phaus los ntawm kev txo qis qab los noj mov thiab txo cov khoom noj. Tsis tas li ntawd, semaglutide kuj tseem tuaj yeem txo qhov kev pheej hmoo ntawm cov kab mob plawv loj (MACE) hauv cov neeg mob ntshav qab zib hom 2.

Hauv Suav teb, Ozempic® (semaglutide) tau pom zoo los ntawm National Food and Drug Administration thaum lub Plaub Hlis Ntuj xyoo no los kho cov neeg mob ntshav qab zib hom 2 (T2D) thiab txhim kho kev tswj ntshav qab zib. Novotel® yog ib qho kev ua yeeb yam ntev ntev glucagon-zoo li peptide-1 (GLP-1) analogue nrog ib nrab-lub neej txog li 7 hnub. Nws yog qhov tsim nyog rau kev txhaj tshuaj txhua lub lim tiam nrog cov ntshav ruaj khov.

Hauv Suav teb, tus naj npawb ntawm cov neeg mob ntshav qab zib tau tshaj 129.8 lab, uas tsuas yog 15.8% tau ua tiav cov qauv tswj ntshav qabzib. Mob ntshav qab zib mellitus ua rau muaj kab mob macrovascular, kab mob microvascular thiab lwm yam teeb meem, uas cuam tshuam rau lub neej zoo ntawm cov neeg mob thiab ua rau lub nra ntawm cov kab mob. Ntawm lawv, kab mob plawv yog qhov ua rau tuag ntawm cov neeg mob ntshav qab zib hom 2. Hauv Suav teb, 1 ntawm 3 tus neeg mob ntshav qab zib raug mob los ntawm kab mob plawv. Kev tswj cov ntshav qabzib tsis zoo thiab kev tswj xyuas tsis zoo ntawm cov hlab plawv thiab cov kab mob metabolic xws li ntshav siab, ntshav lipids, thiab lub cev hnyav yog qhov laj thawj tseem ceeb rau kev muaj teeb meem loj hauv Suav cov neeg mob ntshav qab zib. Yog li, kev kho mob ntshav qab zib yuav tsum tau tsom mus rau tag nrho cov txiaj ntsig ntawm cov neeg mob, suav nrog kev tswj hwm cov ntshav qabzib thiab cov txiaj ntsig ntawm cov hlab plawv, thiab tswj hwm ntau yam kev pheej hmoo.

Raws li cov khoom lag luam blockbuster GLP-1 tswj hwm ib hlis ib zaug, Novotel® siv cov thev naus laus zis los txuas ntxiv ib nrab-lub neej mus rau 7 hnub, ua tiav ib zaug ib lub lim tiam, muaj zog tswj cov suab thaj, ua kom raug raws li cov qauv, thiab tau txais txiaj ntsig los ntawm kev ua haujlwm ntawm cov hlab plawv. , Txhawm rau muab kev kho mob zoo dua, yooj yim thiab nyab xeeb rau Suav cov neeg mob ntshav qab zib hom 2. Qhov kev pom zoo ntawm Novotel® yuav txhawb ntxiv kev hloov pauv ntawm Tuam Tshoj' txoj kev kho mob ntshav qab zib thiab cov ntsiab lus kho mob, pab kev tswj hwm kab mob, txhim kho cov txiaj ntsig kev kho mob mus ntev, thiab pab cov neeg mob rov qab mus rau lub neej nyob kaj siab lug.