Kev Kho Mob Mob Pluas Khov Kho Mob CD 39 Tus Kws Tshuaj / Tshuaj Keytruda Kev Kho Mob Los Sib Yuav Yog Yuav Mus Rau Tsev Kho Mob

Niaj hnub no, immuno-oncology lub tuam txhab Surface Oncology tshaj tawm tias nws tau mus txog qhov chaw kuaj mob koom tes nrog Merck (MSD) los tshuaj xyuas nws txoj kev txhim kho CD 39 inhibitor SRF 617, nrog rau Merck&# {{3 }}; s hnyav dua li PD-1 inhibitor Keytruda Kev nyab xeeb thiab ua tau zoo ntawm cov neeg mob qog. Txoj kev kho ua ke no yuav yog ib qho tseem ceeb ntawm SRF 617' s thawj theem 1 / 1 b kev soj ntsuam kev kawm, uas yuav tsom mus rau kev kho mob cancer hauv plab thiab cov neeg mob qog noj ntshav uas tawm tsam cov tshuaj tiv thaiv kab mob.

SRF 617 yog CD 39 inhibitor. CD 39 yog qhov tseem ceeb enzyme nyob rau hauv kev txiav txim siab thiab tsim tawm ntawm adenosine triphosphate (ATP). Qhov ntau ntawm cov kev tshawb fawb tau lees paub lub luag haujlwm ntawm CD 39 hauv kev tiv thaiv qog noj ntshav. Piv txwv li, hauv kev mob plab, kev tiv thaiv kab mob hauv cov qog feem ntau nthuav tawm qib CD 39. Txawm hais tias cov tshuaj tiv thaiv-tiv thaiv PD-1 tam sim no, qhov no yuav ua kev puas tsuaj tag nrho los tiv thaiv tus mob qog nqaij hlav cancer. Kev sib xyaw ua ke nrog SRF 617 thiab Keytruda muaj lub peev xwm los kov yeej cov nyom no uas cuam tshuam kev ua kom lub cev tiv thaiv kab mob thiab txhim kho kev tiv thaiv qog.

GG quot; Nto Oncology tau cog lus los tsim kev pabcuam daws teebmeem los txhim kho kev kho mob qog nqaij hlav cancer. Kev koom tes nrog Merck yuav ntxiv qhov tseem ceeb rau kev txhim kho kev kho mob ntawm SRF 617 thiab tso cai rau peb soj ntsuam nws cov kev kho mob kom sai dua," Tus Thawj Tuav Haujlwm ntawm Oncology Medical Dr Robert Ross tau hais tias:" Peb tau ua hauv kev tshawb nrhiav pom tias kev tiv thaiv CD 39 ua rau muaj kev tiv thaiv zoo ntawm kev tiv thaiv kabmob thiab kho lub cev tsis muaj zog. Ua kom zoo siab, peb kuj tseem pom Qhov sib xyaw ua ke ua kom zoo dua qub thiab txoj kev sib txuas ua ke no muaj qhov cuam tshuam los mus kov yeej cov kev tiv taus ntawm PD-1."