Peb Xwm Nyob Rau Tib Hnub! Muab Cov Kev Pom Tshiab Tshiab Los txhim kho Qhov Ua Tau Los Ntawm Kev Kho Mob Cancer

Cov ntawv xov xwm sab saud Xwm tau luam tawm peb daim ntawv nyob rau tib lub sijhawm ntawm lub lim tiam dhau los, muab lub zeem muag tshiab rau kev txhim kho qhov ua tau zoo ntawm kev tiv thaiv kab mob cancer.

Peb txoj kev tshawb fawb ywj pheej los ntawm Fab Kis Lub Tebchaws ntawm Kev Noj Qab Haus Huv thiab Kev Tshawb Nrhiav Kev Kho Mob (INSERM), University of Texas MD Anderson Cancer Center, thiab Lund University, Sweden, ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kabmob - B hlwb, sawv ntawm qhov tsom teeb tiv thaiv qog.

When it comes to immunotherapy, many readers may not be unfamiliar. This innovative method of cancer treatment, by mobilizing the patient & #39;s own immune system to fight against tumors, has allowed many previously untreated cancer patients to miraculously escape the death claw.

Unfortunately, immunotherapy is not a panacea. Only about 20% of patients currently receiving immunotherapy receive lasting clinical benefits. Why do some patients have better results? If you can figure out the principles, it will help develop new therapies and benefit more patients.

Cov kev txhaj tshuaj tiv thaiv kab mob niaj hnub tsom mus rau killer T hlwb hauv lub nruab nrog cev, txhim kho lawv lub peev xwm kom paub thiab tua cov qog nqaij hlav cancer. Peb daim ntawv peb kuj qhia tias T cell tsis yog tib lub cev tiv thaiv kab mob uas muaj peev xwm mus tua mob qog nqaij hlav cancer.

These three studies have observed in groups of patients with different types of cancer that when B cells form a cluster of cells called & quot;tertiary lymphoid structures (TLS) & quot; in the tumor, patients receiving immunotherapy will Have better results.

Xibfwb kev tshawb fawb Fridman & # 39; s kev tshawb fawb pawg tau txheeb xyuas cov ntaub ntawv qhia txog noob keeb kwm ntawm ntau dua 600 daim ntaub sarcomas muag muag thiab muab faib cov hnoos qeev coj los sib faib ua pab pawg raws cov yam ntxwv ntawm lub cev tiv thaiv kab mob. Lawv tau pom tias cov pawg B - yog qhov muaj zog tshaj plaws ntawm kev ua kom muaj peev xwm, thiab tias B - ntawm tes - pawg muaj zog tiv thaiv kab mob tau muaj kev tiv thaiv zoo tshaj plaws tom qab tau txais kev tiv thaiv - PD1 kev kho mob hauv kev sim tshuaj mob.

Qhov kev tshawb nrhiav zaum ob tau tshawb nrhiav txog lub luag haujlwm ntawm B hlwb hauv kev kuaj mob piv txwv rau tus mob melanoma, thiab pom tias CD 8- zoo T cell thiab CD 20- zoo B cell tau tshwm sim ib txhij, kwv yees tus muaj sia nyob ntau dua rau cov neeg mob. Kev tsom xam ntawm cov qauv molecular phenotype qhia tau tias lub tsev pheebsuab lymphatic ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob ua rau lub cev muaj cov kab mob melanoma, muab T cell txawv phenotypes.

Qhov kev tshawb nrhiav thib peb ua ntej piv cov qog uas tau teb thiab ua tsis tiav rau kev kho mob hauv cov neeg mob melanoma. Cov txiaj ntsig ntawm kev ntsuas loj - nplai RNA ua ntu zus qhia tau tias B - xov tooj ntawm tes yog cov caj ces nrog qhov sib txawv tshaj plaws ntawm kev hais tawm ntawm ob hom qog. Cov kev tshawb nrhiav pab pawg tau siv ob pawg neeg mob cov neeg mob raum cell carcinoma thiab melanoma uas tau kho nrog cov tshuaj tiv thaiv kab mob hauv lub cev.

& quot;We found that B cells are not idle bystanders, but also make a meaningful contribution to the immune response against tumors, & quot; said study author Dr. Beth Helmink, University of Texas Anderson Cancer Center.

B cell yog ib hom kab mob tiv thaiv kab mob uas tsim cov tshuaj tiv thaiv. Txawm hais tias nws tsis paub meej li cas B cov hlwb hauv kev ua haujlwm ntawm lymphoid tus qauv ua haujlwm, cov kws tshawb fawb xav tias B hlwb ntawm kab mob ua ntej ntawm antitumor yuav tsim cov tshuaj tiv thaiv kom tua tau cov kabmob kheesxaws, lossis lawv yuav ua haujlwm los ntawm kev txhawb nqa T cell.

& quot; Xwm & quot; tau tawm lus pom zoo heev rau qhov kev tshawb pom no, thiab tshaj tawm tshwj xeeb cov lus tshawb xyuas. Immunologist Professor Tullia Bruno taw qhia hauv qhov kev soj ntsuam tias qhov no cov ntaub ntawv & quot; yog cov tswv yim pom zoo thiab siv cov ntaub ntawv hais txog cov chaw kuaj mob los coj B hlwb thiab qib siab lymphatic cov qauv rau lub hauv ntej ntawm anti - kev tiv thaiv qog. & quot; Cov txiaj ntsig no tseem tau taw rau qhov kev coj ua tshiab rau kev tshawb nrhiav tom qab. Kev sib txuas ntawm T cell - ntawm kev kho kom haum xeeb thiab kev siv hom B ntawm tes yuav tsum coj cov tshuaj anticancer zoo rau cov neeg mob ntau dua. (los ntawm Bioon.com, sau hsppharma.com)