Tus Teev ntawm Tshuaj Intermediates Los Ntawm Tshuaj Mus Txog Tshuaj

Qhov cuam tshuam ntawm kev cuam tshuam ntawm kev lag luam thoob ntiaj teb rau Tuam Tshoj kev lag luam yog qhov muaj txiaj ntsig tshaj li nws lub tswv yim tias txhua qhov chaw tsim khoom tsis tas yuav tsum loj thiab yuav tsum tsom nws cov nyiaj thiab lub zog ntawm lwm cov ntaub ntawv txhawb thiab cov kev mob hauv kev lag luam thiab teb uas nws zoo. ntawm. Raws li lub tswvyim ntawm lub tswvyim kev lag luam, kev lag luam kws tshuaj tuaj yeem hloov qee cov kev lag luam ntawm cov khoom tseem ceeb xws li cov kuab tshuaj rov qab rau cov koom tes sib koom tes, thiab maj mam txo qee qhov muaj kuab paug thiab cov khoom tsis zoo raug xa mus rau cov nroj tsuag tshuaj rau ntau lawm. Piv txwv li, phenylacetic acid chloroacetic acid siv hauv kev tsim cov tshuaj penicillin tau nyob ze thaj tsam ntawm Shijiazhuang. Txij li xyoo 1970, coob ntawm cov chaw lag luam hauv nroog thiab cov neeg lag luam ib leeg tau tsim rau cov phenylacetic acid thiab chloroacetic acid hauv North China Pharmaceutical.

Raws li kev koom tes ntawm ob tog txuas ntxiv mus tob zuj zus, cov tuam txhab ua lag luam tshuaj maj mam hloov qee cov khoom lag luam uas muaj nqi ntau nrog cov nqi siab dua rau cov nroj tsuag tshuaj. Piv txwv li, arsenic acid AE-active ester triazine nplhaib tetrazolium acetate yog siv rau kev tsim cov tshuaj tua kab mob cephalosporin. Cov khoom lag luam xws li phenylglycine (Deng potash) HO-EPCP tau qhib cov ceg kev lag luam los tsim kho sai sai hauv xyoo 1990. Tus naj npawb ntawm cov kws tshuaj nruab nrab nrog cov txiaj ntsig ntawm kaum tawm lab rau 100 lab yuan, xws li Zhejiang Yongning Pharmaceutical Factory Fushun Meiqiang Pharmaceutical Factory Zhejiang Hengdian Debang Group Shandong Ruiying Group Shandong Jincheng Tshuaj Tsob Nroj thiab ntau lwm cov tuam txhab tau tsim kev lag luam kom ze dua kev koom tes nrog cov tuam txhab kws tshuaj. Cov ntaub ntawv raw (kab mob hmoov) ncaj qha sib tov los ntawm cov tuam txhab tsim cov tshuaj intermediates. Cov khoom lag luam raug muag hauv daim ntawv ntawm cov khoom siv tshuaj rau cov tuam txhab ua tshuaj rau kev ua kom zoo thiab tom qab ntawd muag ua lag luam tshuaj. Tus kws tshuaj nruab nrab tuaj yeem txuas ntxiv cov khoom lag luam, nce nyiaj ntawm cov khoom lag luam thiab txhim kho kev ruaj ntseg ntawm kev muag khoom, thaum lub tuam txhab tshuaj txo qis kev nqis peev. Tsom rau cov ntawv qhia aseptic uas koj ua tau zoo. Vim tias tsis muaj cov khoom kho mob hauv kev lag luam kws tshuaj nruab nrab. Kev tsim cov ntawv tso cai cov tshuaj lag luam tsis tuaj yeem sib tw nrog kev ua lag luam thiab yog li kev koom tes ntawm ib qho kev ua tiav.