Kev Tshawb Nrhiav Kev Tshawb Fawb Txog Ntawm Biomimetic Tag Nrho Sib Tham Ntawm Quinone Cov Khoom Ntuj

Benvitimod (3,5-Dihydroxy-4-isopropylstilbene) yog lub cim tshiab ntawm cov tshuaj tiv thaiv, tam sim no feem ntau siv los kho ntau yam kab mob autoimmune, xws li psoriasis, psoriasis, eczema thiab lwm yam kab mob ua xua. Thaum Lub Ob Hlis 2020, Jason M. Crawford pab pawg ntawm Yale University tau cais ob yam khoom ntawm dimer dimer ntawm phenenmod los ntawm P.Luminescens nrog muaj zog redox tej yam kev mob thiab eutrophication thawj zaug: carbocyclinone-534 thiab duotap-520, tus qub muaj tseeb inhibit kev loj hlob ntawm mycobacteria, tom kawg muaj qhov tseem ceeb los tiv thaiv staphylococcus aureus thiab enterococcus. Nyob rau tib lub sijhawm, pab neeg tau thov tawm tswv yim los ntawm carbocyclinone-534 (Angewandte Chemie International Edition, 2020, 59, 7871-7880.).

Pab pawg tshawb fawb ntawm Deng Jun ntawm Pawg Khoom Siv Khoom Siv Khoom Siv Hluav Taws Xob ntawm Kunming lub koom haum ntawm Botany, Suav Academy ntawm Kev Tshawb Fawb tau tsom mus rau biomimetic tag nrho cov khoom sib txuas ntawm quinone ntuj cov khoom hauv xyoo tsis ntev los no. Coj mus rau hauv tus account lub cim qauv tshwj xeeb thiab cov kev ua haujlwm zoo hauv kev ua kom muaj zog ntawm ob lub molecules, pawg neeg tshawb fawb tau tsim tag nrho cov kev tshawb fawb hluavtaws.

Kev tshawb fawb ua ntej xa cov khoom siv triphenol intermediates kom tau zoo los ntawm 6-kauj ruam xws li Wismeier cov tshuaj tiv thaiv thiab HWE cov tshuaj tiv thaiv, thiab tom qab ntawd tsim qhov tseem ceeb nruab nrab hydroxyquinone dimerization cov khoom los ntawm potassium ferricyanide oxidation nyob rau hauv ib kauj ruam, thiab thaum kawg catalyzes iodine thiab divalent tooj liab Dehydrogenation ua tiav tag nrho cov tshuaj lom ntawm carbocyclinone. -534. Thaum ua tiav biomimetic tag nrho cov lus sib xyaw ntawm cov qauv hauv 8 cov kauj ruam nrog cov kauj ruam ntev tshaj plaws, ua ke nrog cov kev sib tw ntawm cov ntawv pov thawj, cov kab mob biomimetic ntawm carbocyclinone-534 tau thov los ntawm Jason M. Crawford' s pab pawg tau raug kho.

Los ntawm 6-kauj ruam tiv thaiv ntawm FC alkylation thiab HWE cov tshuaj tiv thaiv, benzenemod monomer tau ua kom zoo, thiab nws tau pom tias nws thiab triphenol intermediates tiav cov synthesis ntawm duotap-520 nyob rau hauv cov xwm txheej ntawm potassium ferricyanide thiab potassium hydroxide. Cov kws tshawb nrhiav Cov txheej txheem ntawm cov tshuaj tiv thaiv tau tshawb xyuas qhov tseeb dhau ntawm cov txheej txheem kev txheeb xyuas qhov tseeb.