Kev Tshawb Fawb Hauv Qhov Kev Ntsuam Xyuas Thiab Kev Evolution Ntawm NAD Cov Kev Hloov Hauv Cov Nroj Tsuag

NAD (nic-nicotinamide adenine dinucleotide) ua cov khoom siv hluav taws xob hloov pauv (coenzyme) koom nrog ntau qhov kev tawm tsam thiab tau paub zoo los ntawm ntau tus kws tshawb nrhiav. Hauv Preiss handler pathway, nicotinic acid (NA) thiab ntau yam ntawm Na derivatives (glycosylation, methylation, thiab lwm yam) tau tshwj xeeb rau NAD kho cov tshuaj hauv cov nroj tsuag, tab sis txog tam sim no, lub tshuab molecular thiab physiological muaj nuj nqi ntawm NA derivatives hauv tsob nroj cov metabolism tsis tau qhia tawm.

Cov kev tshawb fawb yav dhau los los ntawm Wang Guodong kev tshawb fawb pab pawg, Lub koom haum ntawm noob caj noob ces thiab kev loj hlob biology, Suav Academy ntawm Sciences tau qhia tias O-glycosylation kev hloov kho ntawm Na yuav tiv thaiv cov nroj tsuag hlwb los ntawm kev mob lom los ntawm kev txuam nrog ntau dhau ntawm Na thaum lub noob qes, thiab cov haujlwm ntawm NAOGT tau maj mam tau txais thaum lub sij hawm kev hloov pauv ntawm Cruciferae Nroj Tsuag, thiab kev tau los ntawm NAOGT kev ua haujlwm tau muab kev xaiv zoo rau cov nroj tsuag kom yoog rau ib puag ncig (Li li al, cog Cell ， 2015）。 Tsis ntev los no, Wang Guodong pab pawg pom tias hauv Arabidopsis, ib qho tshiab hom N-methyltransferase (NANMT, At3g53140 code) yog lub luag haujlwm rau kev tsim cov nicotinic acid N-methylated tebchaw (tseem hu ua cucurbitacin). Lub sijhawm no, N-methylated nicotinic acid kev hloov kho yog lwm hom kev tshem tawm cov nroj tsuag NA. kev hloov pauv thiab kev tshawb nrhiav biochemical qhia tau hais tias kev ua haujlwm ntawm qhov tshiab no nicotinic acid N-methyltransferase los ntawm kev rov ua dua thiab kev ua haujlwm sib txawv ntawm COMT (caffeic acid O-methyltransferase) noob, uas koom nrog biosynthesis ntawm tsob ntoo lignin. Lub qub COMT ntawm cov nroj tsuag tseem khaws cov haujlwm NANMT tsis muaj zog, uas qhia tau tias tau los ntawm NANMT kev ua haujlwm tau pab txhawb rau Preiss handler pathway khaws cia hauv thaj av cog qoob loo genome thaum kev hloov pauv ntev ntawm cov nroj tsuag.

Cov ntaub ntawv tshawb fawb tau muab tshaj tawm nyob hauv online ntawm Tsob ntoo Physiology (DOI: 10.1104 / pp.17.00259) Lub Tsib Hlis 22. Li Wei, Zhang Fengxia thiab Wu Ranran ntawm Wang Guodong pawg neeg tshawb fawb yog cov sib koom ua ke ntawm cov ntawv no. Qhov dej num tau txhawb los ntawm NSFC, "973" txoj haujlwm ntawm Ministry of Science thiab technology thiab State Key Laboratory ntawm tsob ntoo genomics. (Los ntawm lub koom haum ntawm kev tshuaj ntsuam genetic thiab kev loj hlob biology, Suav cov kev kawm ntawm kev tshawb fawb, suav los ntawm www.hsppharma.com)