NEJM: Cov Tshuaj Tshiab Yuav Siv Tau Los Kho Schizophrenia

Raws li kev tshawb nrhiav tawm nyob rau hauv New England Journal of Medicine lub Plaub Hlis 16, SEP-363856 (uas tsis yog D 2 cov tshuaj uas muaj cov kab mob uas muaj cov kab mob amine-txuam receptor {{6} } (TAAR 1) thiab serotonin hom 1 Ib qho kev ua si) muaj qhov cuam tshuam pom tseeb. Rau cov neeg mob hais los saum toj no, cov tsos mob ntawm cov neeg mob kho nrog SEP-363856 tau nqis qis dua li cov ntawm cov placebo pawg.

Dr. Kenneth S. Koblan los ntawm Sunovion Pharmaceuticals, Marlborough, Massachusetts thiab cov npoj yaig tau sim kev pheej hmoo los soj ntsuam qhov ua tau zoo thiab kev nyab xeeb ntawm SEP-363856 hauv cov neeg laus uas muaj kev mob siab ntawm schizophrenia. Cov neeg mob tau muab lub sijhawm cia li tau txais SEP-363856 lossis placebo ib hnub ib zaug rau tag nrho ntawm 4 lub lis piam (120 thiab 125 cov neeg mob, feem).

Cov kws tshawb nrhiav tau pom tias qhov nruab nrab hloov pauv ntawm tag nrho cov qhab nia ntawm PANSS hauv pab pawg SEP-363856 thiab pawg placebo yog -17. 2 cov ntsiab lus thiab -9. 7 cov ntsiab lus, feem. Nyob rau lub asthiv thib plaub, cov kabmob ntsig txog cov kabmob (Cov Neeg Cuam Tshuam Thoob Ntiaj Teb, qhov luv luv ntawm cov qhab-nees tsis zoo) ntawm pab pawg SEP-363856 txhua tus poob qis. Tsis tas li ntawd, kev qaug zog thiab mob plab hnyuv plab tau raug cais raws li cov kev mob tshwm sim ntawm SEP-363856; ib qho kev mob plawv sai sai tau tshwm sim hauv pawg SEP-363856.

GG quot; Tsab ntawv ceeb toom los ntawm Koblan li al. Tsis tsuas yog qhia txog cov kev cog lus zoo siv tshuaj kho kom zoo, tab sis tseem muab cov pov thawj ntxiv raws cov txheej txheem tsis paub txog cov tshuaj uas TAAR 1 yog lub hom phiaj zoo," tus sau' s tsab xov xwm Wrote. Cov kev tshawb fawb tau nrhiav nyiaj los ntawm Sunovion Pharmaceuticals, tus tsim tawm ntawm SEP-363856.