Gilead Biktarvy Muaj Kev Nyab Xeeb thiab Zoo Nyob Hauv Pab Pawg Neeg Laus Nrog Tshawb Xyuas ≥65 Xyoo Lawm Thiab Tau Npe Nyob Hauv Suav Teb!

Tsis ntev los no Gilead Kev Tshawb Fawb tau tshaj tawm cov tshuaj HIV tshiab peb-hauv-ib qhov sib xyaw ua yeeb tshuaj tshiab Biktarvy (hom npe: Bicenprenor ntsiav tshuaj, Bictevirir 50mg / Emtricitabine 200mg / Propofol Tenofovir 25mg, BIC / FTC / TAF) Kev tshuaj xyuas tshiab ntawm cov ntaub ntawv tau lees tias hauv cov neeg laus (n=140) uas muaj hnub nyoog ≥65 xyoo thiab tau ua tiav kev tiv thaiv virological, kev kho mob nrog Biktarvy muaj kev ua tau zoo thiab kev nyab xeeb, suav nrog cov neeg laus laus uas muaj cov mob ua kom zoo, xws li mob ntshav qab zib, kub siab, mob plawv, thiab dyslipidemia. Tom qab hloov mus rau Biktarvy hauv cov neeg mob no, 92% ntawm lawv tau saib xyuas tus kabmob txhawm rau lub asthiv 48 (HIV RNA< 50="" daim="" ntawv="" ml).="" cov="" ntaub="" ntawv="" no="" los="" ntawm="" kev="" tshawb="" nrhiav="" qhov="" kev="" ntsuam="" xyuas="" ntawm="" 4="" qhov="" kev="" sim="" thoob="" ntiaj="" teb.="" hauv="" txhua="" qhov="" kev="" sim,="" biktarvy="" feem="" ntau="" ua="" tau="" zoo.="" cov="" txiaj="" ntsig="" ntsig="" txog="" yuav="" tau="" tshaj="" tawm="" ntawm="" 23th="" international="" kev="" sib="" tham="" txog="" aids="" (aids="" 2020,="">

Kev hais ntawm ncauj OAB0403-Cov ntsiab lus luv luv tsom xam ntawm Biktarvy' s kev kho mob ntawm cov neeg laus laus ≥65 xyoo hauv 4 qhov kev sim thoob ntiaj teb: cov txiaj ntsig ntawm lub lim tiam 48

Kev ntsuam xyuas tag nrho 4 qhov kev sim thoob ntiaj teb (1844, 1878, 4030, thiab 4449 kev tshawb fawb) tau txheeb xyuas los soj ntsuam cov kab mob voos (HIV-1 RNA< 50="" daim="" ntawv="" ml),="" kho-paub="" dhau="" los,="" thiab="" muaj="" hnub="" nyoog="" ≥65="" cov="" laus="" neeg,="" siv="" kev="" kho="" mob="" biktarvy="" rau="" ua="" kom="" tau="" txais="" txiaj="" ntsig="" thiab="" kev="" nyab="" xeeb.="" raws="" li="" kev="" ntxig="" ntsig="" los="" ntawm="" us="" fda,="" thawj="" qhov="" kawg="" yog="" tus="" kab="" mob="" viag="" kis="" ntawm="" lub="" limtiam="" 48="">< 50="" daim="" ntawv="" ml).="" hauv="" cov="" kev="" tshawb="" fawb="" no,="" muaj="" tag="" nrho="" 140="" tus="" neeg="" mob="" (hnub="" nyoog="" nruab="" nrab:="" 68="" xyoo)="" tau="" suav="" nrog="" kev="" ntsuas,="" 14%="" yog="" poj="" niam="" thiab="" 88%="" yog="" neeg="" tawv="" dawb.="" hom="" comorbidities="" ntawm="" lub="" hauv="" paus="" muaj="" xws="" li:="" mob="" ntshav="" qab="" zib="" (22%),="" ntshav="" siab="" (55%),="" mob="" plawv="" (24%),="" thiab="" dyslipidemia="">

Cov ntaub ntawv qhia tau hais tias nyob rau lub asthiv 48, qhov kev faib ua feem ntawm cov neeg mob HIV-RNA< 50="" daim="" ntawv="" ml="" yog="" 92%="" (129/140),="" qhia="" tias="" biktarvy="" tau="" tuav="" tus="" kab="" mob="" loj="" dua="" ntawm="" cov="" neeg="" laus.="" hauv="" cov="" kev="" tshawb="" fawb="" no,="" biktarvy="" yog="" feem="" ntau="" tau="" ua="" siab="" zoo;="" 11="" cov="" neeg="" mob="" muaj="" qib="" 1="" lossis="" qib="" 2="" kawm="" txog="" cov="" tshuaj="" cuam="" tshuam="" txog="" tshuaj="" (ae),="" thiab="" 4="" ntawm="" lawv="" tsum="" tsis="" kawm="" ntxiv.="" tsis="" pub="" muaj="" qib="" 3="" lossis="" 4="" txog="" tshuaj="" phiv="" lossis="" tshuaj="" tiv="" thaiv="" kev="" ploj.="" feem="" ntau="" cov="" kev="" phiv="" tshuaj="" yog="" nasopharyngitis="" thiab="" mob="" caj="" dab="" (7%="">

Raws li tus naj npawb ntawm cov neeg laus kis tus mob HIV tseem muaj ntau ntxiv, nws yog ib qho tseem ceeb rau txoj kev kho kom zoo kom tau raws li qhov xav tau tshwj xeeb ntawm cov neeg tseem ceeb no, suav nrog cov neeg muaj tus kab mob mus ntev uas yuav xav tau ntau yam tshuaj. Thaum xyoo 2030, kwv yees tias muaj li 70% ntawm cov neeg muaj tus kabmob HIV yuav muaj hnub nyoog tshaj li 50 xyoo, thiab lawv feem ntau yuav muaj tsawg kawg ib zaug ntxiv. Cov ntaub ntawv tshaj tawm ntawm lub rooj sib tham AIDS 2020 tau lees paub tias kev siv Biktarvy kev kho rau cov neeg laus hnub nyoog 65 thiab siab dua tuaj yeem tswj hwm kev tiv thaiv zoo, thaum sib cuam tshuam nrog cov ntshav lipid (xws li cov roj cholesterol), hnyav, lossis lwm yam tshuaj uas yuav tsum tau noj vim tias mus rau comorbidities Tsis muaj qhov cuam tshuam loj.

Biktarvy yog ib ntsiav tshuaj tsuas yog noj kiag (STR) noj ntawm ncauj ib hnub ib zaug rau kev kho mob HIV-1. Cov tshuaj sib xyaw nrog cov potency ntawm ib tug tshiab integrase saw hloov inhibitor (INSTI) bictegravir (bicativir, BIC) thiab cov tshuaj lag luam Descovy, emtricitabine propofol tenofovir ntsiav tshuaj, FTC / TAF) tau muaj pov thawj kev ua tau zoo thiab muaj kev nyab xeeb, tom kawg yog ob qho txiaj ntsig nucleoside reverse transcriptase inhibitor (NRTI) kev kho mob taub hau uas tau pom zoo los ntawm HIV cov lus qhia txog kev kho tus mob. Kev soj ntsuam hauv Ntu III pom tias Biktarvy ua tiav tau zoo heev ntawm kev tiv thaiv kab mob ntawm cov neeg mob uas tsis tau txais kev kho mob yav tas los (kev kho mob thib ib) thiab cov neeg mob uas tau ua tiav tus mob vauv thiab hloov kho kev kho mob (kev kho mob thib ob), thiab tsis muaj kev kho mob tshwm sim ntawm tshuaj tiv thaiv.

Biktarvy tau pom zoo los ntawm Asmeskas FDA thaum Lub Ob Hlis 2018. Cov tshuaj no tsim nyog siv los ua kev cai tag nrho rau kev kho mob rau menyuam yaus thiab cov neeg laus nrog tsawg kawg 25 kg ntawm HIV-1 mob, suav nrog: (1) kev kho thib ib: rau tsis muaj kev mob rau cov neeg mob uas muaj keeb kwm tshuaj tua kab mob; (2) Kev kho ob-kab: siv los txais kev kho mob ruaj khov kho kom ua tiav cov tshuaj tua kab mob, tsis muaj keeb kwm ntawm kev kho tsis ua hauj lwm, thiab tsis muaj kev paub tsis kam tiv thaiv ib qho kev tiv thaiv ntawm Biktarvy, Hloov nws cov kev siv tshuaj tiv thaiv tam sim no.

Hauv Suav Teb, Biktarvy tau pom zoo los ntawm Hong Kong thaum Lub Kaum Hlis 2018 thiab pom zoo los ntawm thaj av loj thaum Lub Yim Hli 2019. Hauv lub tebchaws loj, cov tshuaj no tsim nyog rau kev kho mob rau cov neeg laus muaj tus kabmob HIV-1 ua ib tus qauv tiav, thiab tsis muaj pov thawj tam sim no thiab yav dhau los ntawm kis kab mob tsis haum rau cov tshuaj tiv thaiv kabmob, emtricitabine lossis tenofovir.