Fluorinated Pyridine Intermediates Ua Kub Kub

Tam sim no, cov tshuaj tua kab mob quinolone uas tau tsim thiab muab tso rau hauv ntau lawm hauv Suav teb feem ntau suav nrog norfloxacin, ciprofloxacin, ofloxacin, enoxacin, lomefloxacin thiab fleroxacin. Ntawm lawv, norfloxacin, ciprofloxacin thiab ofloxacin tsim cov khoom lag luam ntau tshaj plaws, uas suav txog 98% ntawm tag nrho cov kev lag luam ntawm cov tshuaj fluoroquinolone antibacterial.

Feem ntau cov quinolones tau txais los ntawm kev coj cov tshuaj fluorine muaj quinolate los ntawm lub nplhaib muaj cov tshuaj fluorine uas muaj lub nplhaib benzene thiab tom qab ntawd ua rau nws xau nrog piperazine (lossis methyl piperazine). Vim muaj cov tshuaj fluorite ntau nyob hauv Suav teb, nws yog ib lub teb chaws uas muaj cov tshuaj fluorine ntau ntau thiab cov tshuaj nruab nrab hauv ntiaj teb, thiab ntau dua 80% cov tshuaj fluorine uas muaj cov tshuaj nruab nrab yog xa tawm. Ntawm tag nrho, Tuam Tshoj tus fluorobenzene intermediates tau tsim ua ntej lawm, thiab kev tsim muaj peev xwm tam sim no feem ntau dhau qhov peev xwm; kev txhim kho ntawm benzotrifluoride intermediates yog qhov lig, thiab qhov kev loj hlob sai dua nyob rau xyoo tas los no; rau heterocyclic uas muaj ntxhiab sib txuas, tshwj xeeb tshaj yog fluorinated pyridines. Chav Kawm, Tuam Tshoj tsuas muaj ob peb pawg kev tshawb fawb thiab cov tuam ntxhab muaj cov thev naus laus zis ntawm fluorine-pyridine intermediates. Yog li, fluorine-muaj pyridine intermediates yuav dhau los ua ib qho ntawm cov lus qhia tseem ceeb rau kev txhim kho ntawm fluorine-muaj intermediates nyob rau ob peb xyoos tom ntej no.