Cov Tshuaj Everest Xerava (eravacycline) Tau Txais Los Ntawm Tuam Tshoj Cov Khoom Siv Tshuaj Kho Mob

Cov tshuaj Everest yog lub tuam txhab biopharmaceutical tsom rau kev tsim kho thiab kev lag luam ntawm cov tshuaj tshiab, muaj siab ua kom tau raws li cov kev xav tau kev kho mob tsis zoo hauv Suav Tuam Tshoj thiab lwm cov khw muag khoom hauv Es Xias. Tsis ntev los no, lub tuam txhab tshaj tawm tias National Medical Products Administration (NMPA) tau lees txais Xerava (eravacycline) hauv Suav teb rau kev kho mob rau cov neeg laus muaj mob sib kis hauv plab (cIAI) kev lag luam tshuaj tso cai lag luam daim ntawv thov.

Nws tsim nyog teev tias qhov no yog thawj zaug Everest Tshuaj tau xa daim ntawv thov kev lag luam tshuaj nyob hauv Suav teb. Cov ntaub ntawv soj ntsuam qhia pom tias Xerava tau qhia txog kev nyab xeeb zoo hauv kev kho mob ntawm tus neeg laus cIAI, thiab cov txiaj ntsig kev tshwm sim tseem qhia tau tias nws qhov kev ua tau zoo tsis qis tshaj ntawm ertapenem (ertapenem) thiab meropenem (meropenem). Yog tias tau txais kev pom zoo, Xerava yuav muab txoj kev kho mob tshiab rau cov neeg laus muaj hnub nyoog ntawm cIAI hauv Suav teb.

Xerava yog qhov tshiab, tag nrho cov khoom siv hluav taws xob, dav-pom, fluorotetracycline, cov tshuaj tua kab mob tau tsim los ntawm Tetraphase Pharmaceuticals (tam sim no yog ib qho kev lees paub ntawm La Jolla Pharmaceuticals). Cov tshuaj no tau pom zoo nyob rau hauv Tebchaws Asmeskas thiab European Union rau xyoo 2018 rau kev kho mob ntawm kev mob hlwb hauv plab (cIAI) hauv cov laus. Lub Plaub Hlis 2020, cov tshuaj tau pom zoo hauv Singapore rau kev kho mob ntawm tus neeg laus cIAI.

Thaum Lub Cuaj Hli 2020, Xerava tau suav nrog cov lus qhia siv tshiab tshaj plaws los ntawm Lub Chaw Haujlwm Tiv Thaiv Kab Mob hauv Tebchaws Meskas (IDSA) rau kev kho tus kab mob-tiv thaiv cov kab mob antimicrobial. Thaum Lub Peb Hlis 2021, cov tshuaj tau suav nrog cov kws tshaj lij muaj kev txawj ntse pom zoo rau kev kuaj mob thiab kev kho mob ntawm cov neeg muaj kab mob hauv plab hauv kev phais mob sib koom tes muab los ntawm Kev Txiav Txim ntawm Tuam Tsev Kho Mob Suav thiab cov Kab Mob Muaj Pov Thawj Kev Tshawb Fawb thiab Kev Tshawb Nrhiav Lus Txhais ntawm Pawg Tshawb Nrhiav Suav. Koom Haum Tsev Kho Mob.

Hauv kev tso cai pom zoo uas tau kos npe nrog Tetraphse Pharmaceuticals, Everest Tshuaj nyiam siv txoj cai tshwj xeeb los tsim thiab ua lag luam Xerava hauv Greater Tuam Tshoj, Kaus Lim Qab Teb thiab qee lub khw tseem ceeb hauv Southeast Asia (suav nrog Indonesia, Malaysia, Philippines, Thaib, Singapore thiab Nyab Laj).

Xerava yog ib hom tshiab ntawm cov tshuaj tua kab mob loj muaj cov tshuaj fluorine uas muaj tetracyclines. Cov ntaub ntawv los ntawm ob ntu tseem ceeb 3 kev tshawb fawb soj ntsuam thoob ntiaj teb qhia tau tias Xerava pom zoo rau cov neeg mob cIAI, thiab cov txiaj ntsig kev tshwm sim tseem qhia tau tias nws qhov kev ua tau zoo tsis qis tshaj rau ertapenem thiab meropenem. Ob txoj kev tshawb nrhiav tseem ceeb hauv ntiaj teb no yog lub hauv paus rau Xerava' s kev pom zoo hauv Tebchaws Europe, Amelikas thiab Singapore.

Kab mob sib kis hauv plab (cIAI) yog kev kis mob nosocomial los yog zej zog muaj kab mob peritonitis los yog qog ua mob los ntawm cov plab hnyuv mus rau qhov kab noj hniav peritoneal. cIAI suav nrog kev mob plab, plab lossis plab hnyuv perforation, peritonitis, appendicitis, cholecystitis, diverticulitis, thiab lwm yam cIAI yog tshwm sim los ntawm cov kab mob sib txawv, suav nrog cov kab mob gram-tsis zoo, cov kab mob gram-zoo thiab anaerobes. Xyoo 2018, muaj txog li 2.9 lab tus neeg mob cIAI hauv Suav teb, thiab tus nqi kis los ntawm cov tshuaj tiv thaiv cov kab mob tau nce ntxiv, txwv cov kev siv tshuaj tua kab mob uas twb muaj lawm.

Xerava yog lub cim tshiab uas muaj peev xwm zoo, muaj cov khoom siv hluavtaws, dav-pom, fluorinated tetracyclines, tshuaj tiv thaiv kab mob, tiv thaiv cov kab mob protein synthesis los ntawm khi rau 30S ribosomal subunits. Cov tshuaj yog siv rau kev kho mob suav nrog feem ntau ntawm Tuam Tshoj First-line empirical ib tus neeg sawv cev rau kev kho mob rau ntau hom tshuaj tiv thaiv kab mob nrog rau cov kab mob Gram-negative thiab Gram-positive kab mob kis tau.