Chav Kawm Tshiab Ntawm Cov Tshuaj Hypoglycemic Twymeeg (imeglimin) Yeej Lub Ntiaj Teb Thawj Pawg

Poxel SA thiab nws tus khub Sumitomo Dainippon Pharma tsis ntev los no tshaj tawm tias Twymeeg (imeglimin hydrochloride, 500mg ntsiav tshuaj) tau pom zoo hauv Nyij Pooj rau kev kho mob ntshav qab zib hom 2. Twymeeg yog hom tshiab ntawm cov tshuaj hypoglycemic hauv qhov ncauj nrog ob txoj hauv kev ua haujlwm. Qhov kev pom zoo no yog thawj zaug uas imeglimin tau dhau qhov kev pom zoo tso npe thoob ntiaj teb, thiab Nyij Pooj yog thawj lub tebchaws pom zoo imeglimin.

Imeglimin yog thawj cov tshuaj hauv chav kawm nrog cov txheej txheem tshiab ntawm kev nqis tes ua (MOA) tsom mus rau kev ua haujlwm tsis zoo ntawm lub cev, uas tuaj yeem txhim kho cov tshuaj insulin tsis txaus thiab insulin rhiab heev, ob qho tib si Nws yog qhov tseem ceeb ua rau muaj ntshav qab zib hom 2. Imeglimin muaj cov txheej txheem sib txawv ntawm kev ua thiab muaj peev xwm kho hom 2 mob ntshav qab zib hauv txhua theem ntawm tus qauv kev kho tam sim no. Nws tuaj yeem siv ua kev kho mob monotherapy lossis ntxiv rau lwm yam kev kho mob hypoglycemic.

Qhov kev pom zoo no yog ua raws cov ntaub ntawv los ntawm Phase III qhov chaw tsim kho qhov project TIMES. Txoj haujlwm suav nrog 3 qhov tseem ceeb Phase III cov kev tshawb fawb (TIMES1, TIMES2, TIMES3), koom nrog ntau dua 1,100 tus neeg mob hauv Nyij Pooj. Hauv cov kev tshawb fawb no, koob tshuaj imeglimin yog 1000 mg ob zaug ib hnub. Hauv tag nrho peb qhov kev sim, imeglimin tau ntsib thawj qhov kawg thiab lub hom phiaj: cov txiaj ntsig tau lees paub qhov ua tau zoo thiab kev nyab xeeb ntawm imeglimin raws li kev kho mob ib leeg, suav nrog kev muag tshuaj qhov ncauj hypoglycemic lossis npaj insulin, hauv kev kho neeg Nyij Pooj hom 2 mob ntshav qab zib, Kev tiv taus.

imeglimin tshuaj qauv

imeglimin yog Poxel' s pioneering khoom uas lub hom phiaj mitochondrial tsis ua haujlwm. Sumitomo Pharmaceuticals tau tsim kev koom tes nrog Poxel thaum Lub Kaum Hli 2017 los tsim thiab ua lag luam imeglimin hauv Nyij Pooj, Tuam Tshoj (suav nrog Taiwan), Kaus Lim Qab Teb thiab 9 lwm lub tebchaws sab hnub tuaj Asia.

Kev pom zoo Nyij Pooj tau ua rau muaj kev them nyiaj tseem ceeb ntawm 1.75 billion yen (kwv yees li 13.3 lab euros) rau Poxel SA los ntawm Sumitomo Pharmaceuticals. Ib qho ntxiv, tom qab cov khoom lag luam mus rau tom khw, Poxel tsim nyog tau txais 2-tus lej nqi raws li kev muag khoom thiab them nyiaj raws li lub hom phiaj kev muag khoom, nce txog 26.5 billion yen (kwv yees li 200 lab euros).

Koichi Kozuki, Tus Thawj Coj Thawj Coj ntawm Sumitomo Pharmaceuticals, hais tias:" Peb ntseeg tias Twymeeg yog cov khoom tseem ceeb ntxiv rau peb cov khoom lag luam ntshav qab zib uas twb muaj lawm los ntawm nws qhov sib txawv ntawm ob txoj kev ua haujlwm, nrog rau kev ua tau zoo thiab nyab xeeb. Raws li cov txiaj ntsig tau txais hauv Phase 2 thiab Phase 3 Raws li cov ntaub ntawv kho mob, peb ntseeg tias nws muaj peev xwm siv los ua kev kho mob ib leeg thiab ua ke nrog lwm cov kev kho mob uas twb muaj lawm, tshwj xeeb yog ntxiv rau peb cov khoom uas muaj hom 2 mob ntshav qab zib. Kev pom zoo ntawm Twymeeg tso cai rau peb muab kev hloov pauv yooj yim dua rau cov neeg mob uas muaj hom 2 mob ntshav qab zib txoj kev kho mob los pab cov neeg mob tswj lawv tus kab mob."

Imeglimin yog thawj zaug hauv chav kawm tshiab ntawm cov tshuaj lom neeg (Glimins) uas muaj tetrahydrotriazine molecules. Nws ntseeg tias imeglimin ua rau mitochondria, los ntawm kev cuam tshuam ntawm cov txiav ua kab mob (txhawb cov piam thaj ntau-nyob ntawm cov tshuaj insulin) thiab cuam tshuam ntxiv rau pancreatic (txhim kho cov metabolism hauv qabzib hauv lub siab thiab cov leeg pob txha [txwv tsis pub gluconeogenesis thiab txhim kho qabzib nqus). imeglimin tuaj yeem ua lub hom phiaj tag nrho peb lub cev tseem ceeb (daim siab, leeg nqaij, txiav txiav) koom nrog hauv qabzib homeostasis. Cov txheej txheem no tseem muaj peev xwm los tiv thaiv endothelial thiab diastolic tsis ua haujlwm, thiab muaj kev tiv thaiv ntawm microvascular thiab macrovascular puas tsuaj los ntawm ntshav qab zib. Ib qho ntxiv, imeglimin tseem muaj peev xwm tiv thaiv kev muaj sia nyob thiab ua haujlwm ntawm β hlwb.

Cov txheej txheem tshwj xeeb ntawm kev nqis tes no muab imeglimin tsis muaj peev xwm los kho hom 2 mob ntshav qab zib hauv yuav luag txhua theem ntawm cov qauv kev kho mob ntshav qab zib tam sim no, suav nrog ua ib qho kev kho mob ib leeg lossis ua kev kho ntxiv rau lwm cov tshuaj hypoglycemic.