Kev kho mob tshwj xeeb mob ntsws ntsws Eli Lilly's VEGFR inhibitor sib xyaw pom zoo los ntawm FDA

Lilly tau tshaj tawm tias Asmeskas FDA tau pom zoo rau lub tuam txhab' s Cyramza (ramucirumab) thiab kev sib koom ua ke erlotinib (erlotinib), kev kho ua ntej-kab nrog nrog cov kabmob epidermal kev loj hlob receptor (EGFR) exon 19 tshem tawm lossis exon Cov neeg mob nrog metastatic tsis cov kab mob ntsws me me (NSCLC) nrog kev hloov pauv exon 21 (L858R). Nrog kev pom zoo no, Cyramza tau tam sim no tau txais rau FDA kev pom zoo rau kev kho qee yam mob ntsws, mob qog nqaij hlav, mob qog nqaij hlav, thiab mob qog nqaij hlav plab hnyuv.

Cyramza ua ke nrog erlotinib yog thawj zaug pom zoo los ntawm FDA, thawj zaug kev kho mob ntawm metastatic EGFR mutant tsis mob qog nqaij hlav hauv hlwb nrog VEGFR / EGFR tyrosine kinase inhibitor kev sib ntxiv ua ke. Qhov kev pom zoo no yog ua raws cov thoob ntiaj teb, xaiv ib qho, tswj hwm qhov chaw hauv cov theem 3 kuaj mob RELAY kev ua tau zoo thiab cov ntaub ntawv muaj kev nyab xeeb.

Hauv kev kawm RELAY, Cyramza (vascular endothelial growth factor receptor 2 antagonist) tau koom ua ke nrog erlotinib (EGFR inhibitor) txhawm rau muab kev pom tseeb thiab kev txhim kho hauv kev muaj sia nyob tsis muaj kev vam meej ntawm cov neeg mob. PFS ntawm Cyramza ua ke txoj kev kho yog 19.4 lub hlis, thiab pawg pawg tswj xyuas yog 12.4 hlis. (HR=0.59; CI, 0.46, 0.76; p<>

RELAY yog Cyramza' s thib ob lub sijhawm 3 kev soj ntsuam kuaj mob nrog cov txiaj ntsig zoo hauv kev kho mob ntawm cov tsis mob ntsws uas tsis yog tes tsawg ntawm lub ntsws. Thawj yog REVEL, uas txhawb kev pom zoo ntawm Cyramza ua ke nrog docetaxel ua cov phiaj xwm kev kho mob rau cov neeg mob uas muaj metastatic tsis mob me me ntawm cov ntsws mob cancer uas cov mob cancer tseem muaj kev vam meej tom qab tau txais platinum-based chemotherapy.

GG quot; Qhov kev kho tshiab tshiab thawj zaug rau kev siv metastatic EGFR-mutated tsis mob me me rau cov ntsws mob ntsws ua rau ob qho tib si VEGFR thiab EGFR txoj hauv kev, thiab yog lub luag haujlwm tseem ceeb hauv kev kho tus mob no." Dr. Edward Garon, tus thawj coj ntawm North American RELAY mus sib hais, University of California, Los Angeles," Nws muab cov kev xaiv kho mob tshiab ua ntej rau cov neeg mob uas tsis yog mob ntsws me me los ntawm lub ntsws nqa EGFR kev hloov pauv."