Cov txheej txheem kev npaj ntawm protein AIE nano point optical sojntsuam

Xyoo 2001, Tang benzhong, tus xibfwb ntawm Hong Kong University ntawm kev tshawb fawb thiab thev naus laus zis, nrhiav pom qhov tshwm sim sib txawv rau cov kev suav ib txwm suav, hu ua kev sib xyaw ua ke emission (AIE). Lub hauv paus ntsiab lus ntawm AIE yog tias vim yog kev txwv ntawm kev txav mus los ntawm cov lus tsa suab, cov kwj deg tsis muaj duab hluav taws xob tau thaiv, thiab cov duab hluav taws xob tau zoo tuaj. Piv nrog rau cov tsoos organic tsoos, AIE cov khoom siv fluorescent muaj qhov zoo ntawm cov muaj zog photobleaching tsis kam, siab fluorescence zoo thiab ntev Stokes tawm chaw. AIE fluorescent cov ntaub ntawv muaj cov ntaub ntawv thov dav dav rau ntau qhov chaw ua haujlwm, xws li kev siv roj ntsha (organelles, hlwb, kab mob me me thiab cov ntaub so ntswg, thiab lwm yam), cov tshuaj lom neeg pom xyoob ntoo (ions, khoom tawg, ntiv tes thiab enzymes, thiab lwm yam), kev kho mob biotherapy, cov khoom tshiab ntse. , kev siv tshuab yees duab, thiab lwm yam Tshwj xeeb tshaj yog nyob rau thaj teb kev lom zem, AIE nanoparticles qhia tau zoo tshwj xeeb. Txawm hais tias ntau qhov kev npaj ntawm AIE nanoparticles tau raug tsim los ntawm kev siv tshuaj, nws tseem muaj qee qhov teeb meem, xws li cov khoom loj dav faib (cov xov tooj ntawm AIE lwg me me hauv txhua qhov me me sib txawv), loj dhau qhov loj me, qhov tsis zoo ntawm lub zog ib puag ncig thiab biocompatibility Cov. Nws maj nrawm los tsim cov txheej txheem npaj tshiab ntawm AIE nanoparticles los txhawb cov ntawv thov ntawm AIE cov ntaub ntawv hauv kev siv tshuaj lom neeg thiab kev kho mob.

Cov protein yog Biological amphoteric lwg me me nrog biocompatibility zoo, biodegradability thiab ntau qhov chaw ua haujlwm. Lawv muaj peev xwm zoo li scaffolds lossis cov qauv hauv kev npaj ntawm AIE nanoparticles. Li Feng, tus kws tshawb fawb ntawm Wuhan Virus Tshawb Xyuas Lub Chaw / cov chaw tshawb xyuas biosafety, Suav Academy ntawm Kev Tshawb Fawb, tau koom nrog txoj kev tshawb fawb hla ntawm cov khoom noj muaj protein thiab nano ntev. Tsis ntev tas los no, pab pawg tau tsim kho AIE nano dots kev npaj tshiab raws li cov neeg tsis zoo ntawm Mini ferritin (DPS) ua tus scaffold, thiab siv nws rau qog cell qog. Lub AIE nano dots npaj los ntawm hom no muaj cov yam ntxwv ntawm kev sib txawv loj (nruab nrab cov khoom loj ntawm 26 nm), ntev emission yoj (tus nqi siab txog 670 nm), siab quantum tawm, zoo stability thiab qis cell cell toxicity. Tsis tas li ntawd, kev sojntsuam tuaj yeem tsim singlet oxygen nyob rau hauv lub teeb dawb irradiation, uas tuaj yeem siv los ua qhov kev sojntsuam tshiab ob hom rau fluorescence imaging thiab photodynamic therapy.