Soxgliflozin kho tau lub plawv tsis ua haujlwm raug tso tawm

Raws li International Diabetes Federation (IDF), kwv yees li 463 lab cov neeg laus thoob ntiaj teb raug mob ntshav qab zib hauv xyoo 2019, thiab kwv yees tias xyoo 2045, cov neeg mob ntshav qab zib tuaj yeem ncav cuag 700 lab. Txawm hais tias kev kho mob ntshav qab zib ua lag luam muaj kev sib tw heev, nrog ntau dua cov neeg mob ntshav qab zib thiab kev loj hlob ntawm comorbidities, tseem muaj cov kev xav tsis txaus nyob hauv khw kho mob ntshav qab zib, tshwj xeeb tshaj yog rau cov kev kho mob uas tuaj yeem muaj txiaj ntsig ntshav qab zib thiab ntshav qab zib tsis muaj txiaj ntsig. zoo tagnrho.

Xyoo tsis ntev los no, ib qho kev tsom xam rau kev txhim kho cov ntshav qab zib tshuaj yog nrhiav cov tshuaj nrog cov hlab plawv (CV) cov txiaj ntsig, suav nrog glucagon-zoo li peptide-1 (GLP-1) receptor agonists thiab sodium-glucose cotransporter 2 (SGLT2) Kev loj hlob sai ntawm cov tshuaj tiv thaiv, tshwj xeeb SGLT2 inhibitors, ib txwm coj kev xav tsis thoob rau cov neeg tsim tshuaj, thiab lawv tseem tabtom tawm!

GG quot; Hla ciam teb" kho mob plawv dhia! Kev tshawb fawb Soxgliflozin tawm

Thaum Lub Kaum Ib Hlis 13-17, lub sijhawm sijhawm hauv nroog, 93 Lub Tebchaws Asmeskas Lub Koom Haum Lub Rooj Sib Tham Hauv Xyoo (AHA 2020) tau qhib hauv online. Hauv lub rooj sib tham, txoj kev tshawb nrhiav zaum kawg SOLOIST-WHF txog kev kho mob ntshav qab zib rau cov neeg mob ntshav qab zib uas muaj lub siab tsis ua haujlwm tau tso tawm. Cov.

SOLOIST-WHF mus sib hais yog peb-theem, ob-dig muag, xaiv chaw, sib sim Thawj qhov kev txiav txim siab thaum xub thawj ntawm kev sim ua ntej yog tsim los rau tag nrho cov thawj neeg mob plawv tuag lossis mus pw hauv tsev kho mob vim lub plawv tsis ua haujlwm, tom qab ntawd hloov mus rau kev mob plawv, kev mus pw hauv tsev kho mob vim lub plawv tsis ua hauj lwm thiab cov neeg mus ntsib xwm ceev.

Cov kev sim kho mob yav dhau los ntawm SGLT2 inhibitor tshuaj rau kev tiv thaiv ua ntej ntawm lub plawv tsis mob tsuas yog tsom rau cov neeg mob ntshav qab zib hom 2 lossis kuaj mob plawv tsis ua haujlwm tab sis cov tsos mob plawv tsis ua hauj lwm. Ob peb cov kev tshawb fawb ntawm SGLT2 inhibitors tau tsom cov neeg mob uas lub plawv tsis ua haujlwm. Cov. Txoj kev tshawb no thawb cov cim qhia ntawm SGLT2 inhibitors rau kev kho mob plawv tsis ua hauj lwm rau cov neeg mob plawv tsis ntev los no uas tsis zoo. Cov txiaj ntsig pom tau hais tias Soxaggliflozin tuaj yeem txo qhov kev tshwm sim ntawm qhov kawg ntawm qhov tshwm sim hauv 25.3% ntawm cov neeg laus cov neeg mob, nrog tus neeg txheeb ze txo ntawm 33.2%. Cov txiaj ntsig no tau ntxiv cov pov thawj tshiab los kho rau lub plawv tsis haum nrog SGLT2 inhibitors.

Tsis tas li ntawd, hauv kev tshawb xyuas pawg me, nws kuj tau pom tias puas rau lub plawv tsis ua haujlwm nrog tshwj tseg ejection feem (HFpEF) lossis lub plawv tsis ua haujlwm nrog kev txo qis ejection fraction (HFrEF), daim ntawv thov soxgliflozin tuaj yeem txo qhov tshwm sim ntawm qhov xaus ntawm qhov xwm txheej, hauv HFpEF Cov nyhuv yog qhov zoo dua rau cov neeg mob (HR: 0.48 vs 0.72), uas muab cov tswv yim tshiab rau kev kho mob ntawm HFpEF.

Soxgliflozin tau pom zoo los ntawm European Union rau hom kab mob 1, tab sis tseem tsis tau muab tso rau siv; thiab Asmeskas FDA tau tsis lees txais cov ntawv thov kev lag luam ntawm ntau yam no. Tsaib no, Sanofi tso tseg txoj haujlwm Soxgliflozin kev txhim kho. Txawm hais tias SOLOIST mus sib hais yuav lig rau Lexicon, qhov kev sim siab qhia tau pom tias Soxaggliflozin muaj txiaj ntsig zoo rau cov neeg mob plawv tsis ua haujlwm nrog kev khaws cia ua ib feem. Tej zaum nws yuav yog xov zoo rau lwm cov neeg sib tw ntawm SGLT2 inhibitors.

Cov txiaj ntsig tau tshaj tawm ntawm AHA 2020 yog los ntawm lub sijhawm tsis ntev ntawm cov kev sim, thiab cov ntsiab lus kawg tau hloov. Cov txiaj ntsig ntawm txoj kev kawm tau raug soj ntsuam los ntawm cov kws tshawb nrhiav dua li ntawm cov koom haum ywj pheej. Xav tias kev kho mob HFpEF tau nyuaj ua txhaum, peb muaj laj thawj yuav tau ceev faj txog qhov tshwm sim no. Txawm li cas los xij, nrog Eli Lilly / Boehringer Ingelheim's Jardiance thiab AstraZeneca's FarxigaHFpEF cov ntaub ntawv tshawb fawb yuav tsum tau tshaj tawm rau xyoo tom ntej, lub peev xwm ntawm cov tshuaj no yuav tawm sai sai.

SGLT2 inhibitors sawv daws tas li! Tso ntawm ntau tus neeg lag luam hauv tsev

SGLT2 inhibitors tau pib pom zoo rau cov neeg mob ntshav qab zib hom 2. Hauv 2019, peb SGLT2 inhibitors tau pom zoo rau cov neeg mob ntshav qab zib hom 1 hauv Europe thiab Nyij Pooj: AstraZeneca's Farxiga (dapagliflozin) thiab Astellas 'Suglat (ipragliflozin) thiab Lexicon tus Zynquista (sotagliflozin).

Txawm hais tias SGLT2 inhibitors muaj qhov tseem ceeb hypoglycemic, lub txiaj ntsig plawv ntawm cov tshuaj no tseem ua rau neeg nyiam mloog ntau. Cov Lus Qhia Txog Kev Mob Ntshav Qab Zib 2019 ESC muab SGLT2 inhibitors ua cov tshuaj pom zoo thawj cov tshuaj rau cov neeg mob ntshav qab zib thiab cov hlab plawv ntshav lossis cov neeg muaj mob hnyav (cov lus pom zoo qib IA); 2020," Asia Pacific Society of Neesrology (APSN) Cov Lus Taw Qhia Kev Siv rau Kev Mob Ntshav Qab Zib Neopropathy" thiab" 2020 KDIGO Kev Siv Lub Chaw Tshuaj: Kev tswj ntshav qab zib hauv cov neeg mob uas muaj mob raum mus ntev" kom meej meej pom zoo SGLT2 inhibitors raws li kev qhia thoob ntiaj teb rau kev siv tshuaj kab thawj zaug rau cov neeg mob ntshav qab zib nephropathy (DKD). Tam sim no, SGLT2 inhibitors yuav muab cov phiaj tshiab rau kev kho mob HFpEF.

Tam sim no muaj ntau yam tshuaj SGLT2 inhibitors ntawm cov lag luam hauv Suav teb, suav nrog dapagliflozin, canagliflozin, empagliflozin, thiab empagliflozin, feem ntau yog txawv teb, tab sis canagliflozin thiab empagliflozin tau yoog. Cov npe kws tshuaj. Rau kev tsim cov tshuaj SGLT2 inhibitors, ntau ntau yam kuj tau nkag mus rau chaw kuaj mob. Ntawm lawv, Jiangsu Hengrui' s Hengligliflozin, Shandong Xuanzhu Tshuaj' s Jiagligliflozin, thiab Guangdong Dongyang Tshav Ntuj' s Rongligliflozin tau nkag mus rau theem III kev soj ntsuam kuaj mob.

Xaus

Nyob rau xyoo tas los no, tau muaj kev nce qib ntau nyob rau hauv thaj chaw muaj ntshav qab zib, tab sis tseem muaj ntau qhov tsis tau siv hauv kev kho mob ntshav qab zib. Kev xav tau kev kho mob ntshav qab zib ntau tshaj yog kev txhim kho kev kho mob kom daws tau qhov cuam tshuam ntawm tus kab mob rau lub neej ntawm cov neeg mob. Txawm hais tias nws tseem yuav pom tias txoj kev kho mob tiag tiag tuaj yeem tshawb pom thiab tsim kho, yuav tsum muaj qee qhov kev cog lus zoo nyob hauv qhov kav dej. Cov.

Txawm hais tias cov txiaj ntsig ntawm SOLOIST-WHF txoj kev tshawb nrhiav tsis yog qhov kev tshawb nrhiav qhov tseeb, nrog kev tshaj tawm ntawm HFpEF txoj kev tshawb fawb cov ntaub ntawv ntawm Eli Lilly / Boehringer Ingelheim's Jardiance thiab AstraZeneca's Farxiga rau xyoo tom ntej, lub peev xwm ntawm cov tshuaj no yuav tawm sai sai no.