Science Phau Ntawv Xov Xwm: Qhia Txog Thrombin thiab Platelets Txhawb Kev Tshawb Pom Kab Mob Cancer

Hauv txoj kev tshawb nrhiav tshiab, cov kws tshawb nrhiav los ntawm Ohio State University Comprehensive Cancer Center thiab lwm lub koom haum tshawb fawb tau qhia txog tias ntshav txhaws ntshav protein thiab platelets hu ua thrombin (thrombin) tuaj yeem txhawb kev mob qog nqaij hlav cancer thiab txwv cov anti - kev tiv thaiv qog noj ntshav zoo li cas. Cov txiaj ntsig kev tshawb fawb tau tshawb pom nyob rau hauv phau ntawv xov xwm Science Kev Txhais Lus Tshuaj rau Lub Ib Hlis 8, 2020, thiab cov npe ntawm cov ntawv yog & quot; 0}} β & quot ;.

Daim duab los ntawm CC 0 Phaj Ntawm Tsoomfwv.

Cov kev tshawb pom no qhia pom tias thrombin hauv cov ntshav ua rau platelets tso kev hloov pauv ntawm txoj kev loj hlob β1 (TGF - β1). TGF - β1 yog paub los txhawb kev muaj mob ntawm lub mis, prostate, txoj hnyuv thiab lwm yam qog nqaij hlav, thiab los tiv thaiv cov kab mob hauv lub cev & # 39; s teb rau mob cancer.

Ntxiv rau, TGF - β1 yog qhov tseem ceeb ntawm qhov tsis ua tiav ntawm kev siv tshuaj kho mob (xws li PD - 1 inhibitors) hauv cov neeg mob cancer. Txoj kev tshawb no yuav muab cov lus qhia tshiab rau dab tsi ua rau cov qog ua kom cov tshuaj tiv thaiv tsis haum thiab ua rau lawv paub txog cov kev kho kom zoo.

Hauv cov qauv tsiaj, cov neeg tshawb nrhiav no pom tias kev txwv tsis pub thrombin kev ua ub no tiv thaiv TGF - release1 tso tawm, ua rau cov qog ua kua nrog PD - 1 inhibitors raug rau cov tshuaj no.

& quot; Hauv qhov kev tshawb fawb no, peb tau piav qhia ncaj qha sib cuam tshuam ntawm thrombin thiab TGF - β1. TGF - β1 yog ib hom qog Thiab cytokines uas muaj peev xwm tiv thaiv kev muaj peev xwm ntawm cov kabmob tiv thaiv kab mob los tua qog. & quot;

Li tau hais, & quot; Peb kuj pom tias kev cuam tshuam hauv lub cev nrog txoj kev tiv thaiv no txwv tsis pub tso TGF - β1 thiab ua rau muaj kev hloov pauv ntawm cov qog microenvironment uas tau txais txiaj ntsig zoo los tiv thaiv - kev tiv thaiv qog ua lub cev. & quot;

Li tau sau tseg tias kev mob qog zoo ib yam li cov qhov txhab uas tsis tuaj yeem kho, uas txuas ntxiv cov coagulation pathway thiab ua rau muaj qhov ntau ntawm thrombin hauv thiab ib ncig ntawm cov qog. Qhov no nyeg ua rau cov ua haujlwm platelet ntev thiab TGF - β1 tso tawm.

Li hais, & quot; Kev hloov ntawm kev loj hlob (TGF) ua lub luag haujlwm tseem ceeb hauv kev kho mob qog noj ntshav. Tshwj xeeb, TGF - β1 hloov cov qog microenvironment hauv txoj kev tiv thaiv cov qog nqaij hlav cancer los ntawm kev tiv thaiv kab mob ntawm tes. & quot;

Li tau hais ntxiv tias cov kev tshawb fawb pom tau tias qhov kev txwv ntawm TGF - β1 txhim kho kev cuam tshuam ntawm kev tiv thaiv kab mob cancer. & quot; Yog tias peb tuaj yeem cuam tshuam rau qhov ua kom tiav lossis kev ua haujlwm ntawm TGF - β1, ces qhov no yuav qhib qhov tshiab rau kev kho mob qog noj. & quot;

Hauv txoj kev tshawb fawb no, Li thiab nws cov npoj yaig tau siv ntshav kuaj ntshav, kab xov tooj ntawm tes, thiab tsiaj qauv los ntawm cov neeg mob qog noj ntshav los mus kawm txoj hauv paus ntawm cov paub tab TGF - β1 qhov tseem ceeb thiab qhov tseem ceeb ntawm kev tiv thaiv kev tso tawm no txhais tau tias kev tiv thaiv qog noj ntshav.

Cov kev tshawb pom tseem ceeb ntawm txoj kev tshawb fawb no suav nrog: (1) ib qho qauv hu ua GARP pom nyob rau saum npoo ntawm platelets los ntawm thrombin cleavage; (2) GARP cleavage ua rau platelets tso TGF paub tab - β1; (3) lysis tso tawm tsim nyog rau kev ua kom platelet TGF - β1; (4) Thaiv cov kabmob thrombin nrog rau cov tshuaj tiv thaiv dabigatran etexilate hloov ntau lub qog ua kom cov qog microenvironment thiab nce cov qog ua rau T cell, cov kab mob tua neeg thiab cov neeg nruab nrab cov lej thiab cov haujlwm ntawm granulocytes.

Li tau hais, & quot; Tshaj tag nrho, peb txoj kev tshawb nrhiav qhia txog kev ua kom muaj kabmob tiv thaiv kabmob kheesxaws, uas cuam tshuam nrog thrombin - sib kho GARP sib kis thiab platelet tso TGF - β1. Nws tseem qhia ntxiv tias kev thaiv GARP kev nkag tau yog ib txoj hauv kev los mus kov yeej kev tiv thaiv qog noj ntshav. Cov txheej txheem tsim tawm cov tswv yim kho kom zoo rau kev tawm tsam. & quot;

Siv:

1.Alessandra Metelli et al. & nbsp;Thrombin pab txhawb kev tiv thaiv qog noj ntshav tawm kev tiv thaiv kab mob los ntawm proteolysis ntawm platelet - khi GARP kom qhib LTGF - β. Science Translational Medicine, 2020, doi:10.1126/scitranslmed.aay4860.

2.Blood - txhaws protein thiab ntshav plasmaets txhawb kev tiv thaiv kev khiav tawm, mob cancer
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