Pfizer thiab IDEAYA kos npe rau cov chaw kho mob R&D kev cog lus koom tes los tsim kho kev kho mob qog nqaij hlav muaj txiaj ntsig

IDEAYA Biosciences tshaj tawm tias nws tau kos npe tus neeg kuaj mob R& D kev sib koom tes pom zoo nrog Pfizer txhawm rau soj ntsuam IDEAYA's protein kinase C (PKC) cov tshuaj loog me me rau cov tshuaj tiv thaiv IDE 196 thiab Pfizer's MEK inhibitor binimetinib ua ke los kho GNAQ GNA 11 noob hloov pauv hauv cov neeg mob uas muaj cov qog ua hlav. , suav nrog metastatic uveal melanoma (MUM), mob nqaij hlav melanoma thiab mob caj dab (CRC) cov neeg mob.

IDE 196 tsim los ntawm IDEAYA yog cov tshuaj tiv thaiv molecule me me tsom PKC. PKC protein kinase tsev neeg nyob rau qhov nruab nrab ntawm MEK / MAPK cov paib thiab cov dej ntws qis ntawm G protein cov paib taw kev. PKC muaj kev koom tes rau qhov kev taw qhia uas cuam tshuam rau kev nthuav dav ntawm tes lossis kev hloov pauv ntawm cov kev cai. Txawm hais tias nws yog ntws los GNAQ lossis GNA 11 noob hloov pauv, lossis PRKC cov noob fusion, tuaj yeem ua rau kev ua haujlwm tas mus li ntawm PKC, thiaj li ua rau mob qog ntshav.

IDEAYA thiab Pfizer yuav tsim Pawg Neeg Tsim Kho Kev Sib Koom Tes (JDC), thiab ob tog yuav txiav txim siab sib koom ua ke thiab sib qhia cov ntaub ntawv ntawm cov txiaj ntsig kev sim. IDEAYA yuav txhawb nqa qhov kev tshawb fawb no thiab Pfizer yuav muab binimetinib rau kev tshawb fawb. Txoj kev tshawb no yuav soj ntsuam cov kev hloov kho, kev ua tau zoo, thiab qhov siv tau ntev ntawm kev kho cov qog neeg mob nrog GNAQ lossis GNA 11 cov noob hloov pauv los ntawm kev thaiv MAP kinase cov paib ntawm ob txoj haujlwm ntawm cov dej ntws los ntawm PKC thiab cov nqes dej ntawm MEK. Ntxiv rau, kev sim tshuaj kho mob kuj tseem yuav kawm txog cov tshuaj muaj yees thiab tiv taus ntawm txhua cov tshuaj sib xyaw. Qhov kev sib hais no yuav tsum pib thaum ib nrab xyoo 2020.

GG quot; Muaj kwv yees li 6, 000 cov neeg mob nrog MNA, mob suab paj nruag, CRC thiab lwm cov qog ua cov GNAQ lossis GNA 11 noob hloov pauv hauv tsib lub tebchaws loj hauv Tebchaws Meskas thiab Europe, thiab muaj tam sim no tsis muaj kev pom zoo lub hom phiaj rau cov kev hloov kho ntawm cov noob tshuaj no," said Yujiro S. Hata, CEO thiab Thawj Tswj Hwm ntawm IDEAYA Biosciences:" Peb cia siab tias yuav soj ntsuam kev soj ntsuam cov neeg muaj peev xwm ntawm binimetinib ua ke nrog IDE 196 hauv cov neeg mob no."