Kev nce qib tshiab tau ua tiav hauv kev sib xyaw tag nrho ntawm Codonopiloneolignanin A, ib yam khoom tshiab ntawm lignans

Tsis ntev los no, pab pawg tshawb fawb ntawm Associate Professor Hongdong Hao los ntawm Tsev Kawm Ntawv Chemistry thiab Tsev Muag Tshuaj ntawm Northwest A& F University tau ua tiav kev nce qib tshiab hauv kev suav tag nrho ntawm Codonopiloneolignanin A, cov khoom lag luam tshiab lignan-based, thiab kev tshawb fawb ntsig txog cov txiaj ntsig tau tshaj tawm hauv" Organic Letters" ;. Gao Zhiyu thiab Professor Ren Li yog tus sau thawj zaug, thiab Associate Professor Hao Hongdong yog tus sau.

Codonopiloneolignanin A yog ib yam khoom tshiab ntawm lignans nrog lub cim tshwj xeeb txuas rau lub cev pob txha uas raug cais los ntawm cov hauv paus hniav ntawm kev siv tshuaj Suav ntau Codonopsis pilosula los ntawm xibfwb Shi Jiangong ntawm Suav Academy ntawm Kev Kho Mob Peking Union Kev Tshawb Fawb Kev Tshawb Fawb hauv xyoo 2015. ntawm cov khoom lag luam ntuj no muaj plaub qhov chaw sib chiral thiab ob lub pentasubstituted benzene rings; yog li ntawd, nws yog qhov nyuaj rau ua tiav nws cov kev sib xyaw tag nrho.

Tsis ntev los no, Hao Hongdong pab pawg tshawb fawb tau pib los ntawm kev lag luam syringaldehyde, thiab sib xyaw benzocycloheptanone 20 ntawm cov gram-scale scale siv Stille txuas thiab Ring-Closing Metathesis (RCM) cov tshuaj tiv thaiv; tom qab, los ntawm nucleophilic cov tshuaj tiv thaiv ntxiv nrog rau lwm qhov aryl fragment tau txuas nrog los tsim ua ntej ntawm cov tshuaj tiv thaiv tseem ceeb. Raws li qhov kev nqis tes ua ntawm SnCl4, intramolecular benzyl carbocation thiab styrene cov qauv txheej txheem chav [3+2] cycloaddition cov tshuaj tiv thaiv tau pom thawj zaug, thiab Codonopiloneolignanin tau ua tau zoo. Qhov tshwj xeeb txuas lub cev pob txha ntawm A tau lees paub los ntawm X-ray ib qho siv lead ua qhov sib txawv, thiab tom qab ntawd pab pawg tiv thaiv raug tshem tawm kom ua tiav tag nrho cov kev sib xyaw ntawm codonopiloneolignanin A hauv 12 kauj ruam.