Johnson&Johnson lub tshuaj tiv thaiv kev tua mob Stelara (Xidano®, Ustinumab) tau pom zoo rau cov cim tshiab!

Johnson& Johnson (JNJ)' s lub chaw muag khoom hauv Suav teb, Xi' ib qho Janssen Co., Ltd., tsis ntev los no tshaj tawm tias nws ob qho tshuaj tiv thaiv, Stelara (hom npe: ustekinumab ), yog ob qho kev npaj, uas yog, Ustinumab txhaj tshuaj rau kev txhaj tshuaj thiab qhov ntshav nqus ntshav. Kev txhaj tshuaj Usinumumab (txhaj tshuaj ntxau ntshav), pom zoo los ntawm Tuam Tshoj National Drug Administration (NMPA), yog qhov tsim nyog rau cov lus teb tsis txaus, tsis teb los yog tsis kam lees rau kev kho mob ib txwm lossis qog necrosis factor a (TNFa) kev tawm tsam cov neeg laus nrog rau kev ua haujlwm loj Crohn' s mob (CD). Stelara (Usulinumab txhaj tshuaj) tau pom zoo thawj zaug hauv Suav teb thaum Lub Kaum Ib Hlis 2017 rau kev kho mob ntawm cov mob hnoos qeev mus rau mob hnyav. Tus neeg laus Crohn' s qhia txog kab mob yog nws qhov thib ob qhia tau pom zoo nyob hauv Suav teb.

Stelara yog thawj qhov kev pom zoo nyob rau hauv "ob lub hom phiaj" interleukin 12 (IL-12) thiab interleukin 23 (IL-23) inhibitor pom zoo hauv Suav teb, qhov kev pom zoo sai no tau txais txiaj ntsig los ntawm Lub Xeev Tsoom Fwv Saib Xyuas Kev Tshuaj Yeeb Rau Lub Tsib Hlis { {4}}, 2019, Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv nrog suav Starno® nyob rau hauv cov npe thib ob ntawm cov chaw khomob xav tau txawv teb chaws tshiab.

Stelara' s kev noj tshuaj yog ib qho kev tso ntshav ib leeg (IV) raws lub cev qhov hnyav thawj zaug pab sai sai txhim kho qhov mob; } lub lis piam, thiab tom qab ntawd 90 mg subcutaneous txhaj tshuaj tau pom zoo txhua txhua 12 lis piam los pab txuas ntxiv tswj tus mob.

Txoj cai 2019 European Crohn' s Colitis Lub Koom Haum Cov Lus Taw Qhia pom zoo kom Stelara siv los ua tus kab mob thawj zaug rau kev tua kab mob los ntawm Crohn' Cov. Nrog tus txheej txheem tshiab ntawm kev ua ntawm interleukins, Stelara muaj cov yam ntxwv ntawm kev pib sai thiab kev tu ncua tas mus li ntawm kev tshem tawm. Kev pom zoo ntawm Stelara' s cov cim tshiab pom tias muaj kev nce qib tseem ceeb hauv kev kho mob ntawm Crohn' s kab mob hauv Suav teb, thiab nws tseem yuav qhia cov kev kho tshiab rau cov neeg mob nrog Crohn' s kab mob hauv Suav teb, tshwj xeeb tshaj yog cov neeg mob hnyav mus rau cov neeg mob hnyav.

Kev pom zoo raug txiav txim siab los ntawm peb qhov kev lees paub, pom ob lub qhov muag tsis pom kev, tswj hwm placebo, ntau lub chaw theem III hauv kev soj ntsuam (UNITI-1, UNITI-2, thiab IM-UNITI). Hauv kev tshawb nrhiav yav dhau los ntawm cov neeg mob uas ua tsis tiav lossis tsis nkag siab txog kev kho mob nrog TNF-a inhibitors (UNITI-1) thiab cov neeg mob uas tsis ua tiav kev kho mob (UNITI-2), cov neeg mob tau txais ib leeg ntawm cov leeg (IV {{{{27} }}} mg / kg) Qhov feem ntawm cov neeg mob uas tau txais cov lus teb soj ntsuam nyob rau ntawm {{9}} lub lis piam tom qab infusion yog 34% (UNITI-1) thiab 56% ( UNITI-2), uas yog qhov loj dua pawg pab pawg. Cov lus teb tseem ceeb hauv cov chaw kho mob tau txais tau nyob hauv ib lis piam, thiab tseem ceeb txhim kho cov tsos mob li ntawm {{1 5}} lub lis piam. Tsis tas li ntawd, hauv kev kawm txij nkawm (IM-UNITI), qhov sib piv ntawm cov neeg mob uas yav dhau los tau txais Sidano® txhua 8 lub lis piam thiab tau txais cov lus teb soj ntsuam tau khaws cov lus teb tseem ceeb (53%) thiab teb ( {{1 9}}%) nyob rau lub limtiam 44 Ntau dua cov pab pawg placebo (36% thiab 44%). Tsis tas li ntawd, {{9}} 9. 5% (txhaj txhua txhua 8 lub lis piam) thiab {{9}} 1. {{27} }% (txhaj txhua txhua 12 lis piam) cov neeg mob tuaj yeem tswj hwm chaw kho mob kom ntev txog 1 5 2 lub lis piam.

Raws li hom kev mob tshwm sim ntawm txoj hnyuv (IBD), Crohn' s mob yog ib yam mob uas ua mob rau txoj hnyuv lossis ua mob rau txoj hnyuv quav. Yav dhau los 20 xyoo, qhov kev tshwm sim ntawm IBD hauv Suav tau nce xyoo los ntawm xyoo, ntawm cov xwm txheej ntawm Crohn' s tus kab mob yuav raug 0. 4 / {39; tus kab mob feem ntau tshwm sim rau cov hluas uas tau nce siab, raug kev txom nyem los ntawm Crowe Eunuch' cuam ​​tshuam cov neeg mob' kev kawm thiab kev ua haujlwm.

Professor Chen Minhu, tus lwm thawj coj ntawm Thawj Tsev Khomob ntawm Sun Yat-sen University thiab tus thawjcoj ntawm Gastroenterology Ceg ntawm Suav Medical Association tau hais tias:" Hauv xyoo tsis ntev los no, qog necrosis factor (TNF-a) inhibitors tau ua si lub luag haujlwm tseem ceeb hauv kev kho mob ntawm IBD, tab sis tseem muaj qee tus Muaj qee cov neeg mob uas ua tsis tau zoo, ploj teb lossis nkag tsis tau. IL-12 / 23 yog lub hom phiaj tseem ceeb rau kev kho tus kabmob Crohn, yog li IL-12 / 23 cov tshuaj tiv thaiv yuav muab cov kev xaiv tshiab rau kev kho cov neeg mob no."

GG quot; Kev kho mob ntawm Crohn' s kab mob yuav tsum tsis yog txoj kev dav dav. Xi' ib qho Janssen zoo siab los ua thawj lub tuam txhab los muab ob txoj kev kho mob sib txawv (Stelara thiab Quaker®) los daws cov kev kho mob tsis ncaj ncees tam sim no ntawm cov neeg thov. "Asgar Rangoonwala, Thawj Tswj Hwm ntawm Xi'an Janssen Lub Tuam Txhab, tau hais txog," Rau ntau dua 30 xyoos, Xi'an Janssen tau cog lus tseg rau cov neeg mob suav. Peb tabtom ua haujlwm nrog cov koom haum tsim nyog kom ntseeg tau tias muaj Starno® thiab txhawb nqa nws ua qhov kev npaj kho mob tshiab tseem ceeb. Peb yuav ua siab ntev thiab siv zog ua kom tsis muaj kab mob yav tom ntej."

Stelara (Usinumumab): yog cov tshuaj tiv thaiv kab mob monoclonal tib neeg uas tuaj yeem ncaj qha rau cov p 40 protein subunits ntawm interleukins IL-12 thiab IL-23 nrog qhov siab sib xws. IL-12 thiab IL-23 yog ib txwm muaj tshwm sim cytokines, uas yog lub luag haujlwm tseem ceeb hauv ob qho tib si kev mob hnyav thiab mob tib neeg lub cev, thiab Crohn' Stelara tau txais kev pom zoo hauv 89 lub teb chaws, thiab yeej" Kev Tsim Khoom Tshaj Plaws khoom" (2010) nyob rau hauv Galen, Canada," Khoom plig Biotechnology khoom zoo tshaj plaws (2011) ​​GG quot; hauv Galen, thiab International Galen Award (2012). Cov.

Stelara yog khoom tseem ceeb ntawm Johnson& Johnson' s nkag mus rau qhov teb ntawm kab mob autoimmune. Cov tshuaj tau tsim tawm $ 6. 361 nphom hauv kev muag khoom hauv 2019, kev nce ntawm {{4}. 4% ntawm {{6} }. Lub Ib Hlis xyoo ntawm lub xyoo no, ib tsab xov xwm (Cov kwv yees hais txog cov khoom lag luam rau 2020) luam tawm nyob rau hauv phau ntawv xov xwm thoob ntiaj teb sab saum toj" Nature" taw qhia tias nrog kev nce ntxiv ntawm kev ntsuas thiab kev nruam txuas ntxiv thiab nkag mus hauv kev ua lag luam, Stelara' s kev muag khoom hauv 2020 Nws xav kom mus txog 7 2 {{ 5}} 1 billion nyiaj daus las US, qeb duas 7 th ntawm" World' s Best-Muag TOP 10 Tshuaj hauv 2020" ;.

Zoo li-zoo li (infliximab): yog lub ntiaj teb' s thawj cov kabmob tiv thaiv qog nqaij hlav necrosis (TNF-a) monoclonal antibody, thiab yog thawj TNF pom zoo rau peb qhov sib txawv ntawm cov kab mob hauv lub plab, rheumatism thiab tawv nqaij kab mob -a inhibitor. Cov ntsiab lus tau pom zoo rau gram® hauv Suav teb suav nrog: kev mob caj dab, mob ankylosing spondylitis, mob plab kiav txhab rau cov neeg laus, Crohn' s kab mob hauv cov laus thiab cov menyuam hnub nyoog tshaj 6 xyoos, fistula crohn&# {{ 1}}; s kab mob thiab psoriasis. Gecko® tau pom zoo hauv ntau dua 100 lub teb chaws.