Vismodegib CAS 879085-55-9

Product Description:

Khoom npe: Vismodegib CAS 879085-55-9

 

Synonyms:

2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide;BROMO-1-NAPHTA

BenzaMide, 2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(Methylsulfonyl)-;

VisModegib (GDC-0449);

 

Chemical & Physical Properties

Cov tsos mob: Dawb rau Off-White Khoom

Kev Ntsuas: 99% +

Kub taw tes: 561.6 ± 5 0.0 degree

Melting Point: 179-181 degree

Molecular Luj: 421.3

Qhov ceev: 1.440

Pka:10.72 ± 0.70

Kev ruaj ntseg: ruaj khov rau 2 xyoos txij li hnub ntawm kev yuav khoom raws li muab. Kev daws teeb meem hauv DMSO lossis ethanol tuaj yeem khaws cia ntawm -20 degree mus txog 3 lub hlis.

 

Daim ntawv thov:

Vimodej targets SMO protein and inhibits Gli activation, thereby inhibiting downstream gene transcription and expression.For the treatment of locally progressive or metastatic basal cell carcinoma in adults who have recurred after surgery or are not well treated with surgery or radiotherapy; One of the most common skin cancers is basal cell carcinoma (BCC), which originates in the surface layer of the skin and does not cause pain to patients. The risk was greatest for skin diseases that were regularly exposed to the sun or ultraviolet light. The development and listing of Vimedji has brought good news to patients with BCC, and its clinical role is important and the target market is huge, and it has to grow into a "giant bomb" class (>$ 1 billion) tshuaj yav tom ntej.

 

 

 

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Cim npe nrov: vismodegib cas 879085-55-9, manufacturers, lwm tus neeg, Hoobkas, yuav, Tshuag

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