Valacyclovir Hydrochloride CAS 124832-27-5

Khoom Piav Qhia:

Khoom Lub Npe: Valacyclovir hydrochloride CAS TSIS TAU: 124832-27-5

Lub ntsiab lus:

2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy) ethyl ester monohydrochloride;

L-Valine 2- (2-Amino-1,6-dihydro-6-oxo-9H-purin-9-ylmethoxy) ethyl Ester Hydrochloride Hydrate;

Valaciclovir;

Tshuaj& Lub Cev Muaj Zog:

Tsos: Dawb rau dawb-dawb crystalline zog

Kev Ntsuas: ≥99.0%

Ceev: 1.55g/cm3

Kub Point: 588.4 ℃ ntawm 760 mmHg

Melting Point: 170-172 ℃

Flash Point: 309.7 ℃

Refractive Index: 1.673

Vapor Siab: 7.95E-14mmHg ntawm 25 ℃

Cov Ntaub Ntawv Kev Nyab Xeeb:

Cov Lus Hais Txog Kev Nyab Xeeb: S26; S36

HS Code: 2933990090

Cov Lus Qhia Risk: R36/37/38

Cov lej phom sij: Xi, Xn

Kev Tshaj Tawm Kev Nyab Xeeb: H302

Lo Lus Teeb: Ceeb Toom

Cim: GHS07

WGK Lub Tebchaws Yelemees: 3

Valacyclovir hydrochloride yog tshuaj tua kab mob siv hauv kev tswj tus mob herpes simplex, herpes zoster, thiab herpes B. Lub hom phiaj: HSV nrog Michaelis-Menten qhov tsis tu ncua thiab tshaj tawm ntawm 1.64 +/- 0.06 mM thiab 23.34 +/- 0.36 nmol/mg protein/5 min, feem. Tus nqi Km zoo ib yam tau txais hauv hPEPT1/CHO cov hlwb thiab hauv cov nas thiab luav cov nqaij thiab Caco-2 hlwb, qhia tias hPEPT1 ua tus tswj lub plab thauj khoom ntawm VACV hauv vitro. Txog kev kho thawj zaug ntawm qhov chaw mos ntawm qhov chaw mos, kev sib piv loj tau pom tias valacyclovir (1 g ob zaug ib hnub) muaj txiaj ntsig zoo li acyclovir (200 mg tsib zaug hauv ib hnub) thaum muab rau 10 hnub. Txog kev kho mob rov tshwm sim, ob qhov kev sim qhia pom tias valacyclovir muaj txiaj ntsig zoo li acyclovir (200 mg tsib zaug ib hnub) nrog kho lub sijhawm 5 hnub. Kev noj tshuaj txhua hnub ntawm 1 g ntawm valacyclovir muaj txiaj ntsig zoo li 2 g txhua hnub. Valacyclovir tuaj yeem txhaj ib zaug ib hnub. Qhov ntau ntawm acyclovir hauv cov ntshav thiab CSF tau ntsuas ntawm lub xeev ruaj khov tom qab 6 hnub ntawm kev kho qhov ncauj nrog 1,000 mg ntawm valacyclovir peb zaug ib hnub. EC50 qhov tseem ceeb ntawm PE thiab AC hauv 3T3 hlwb yog 0.02 thiab 0.01 ug/ml, thaum tus nqi hauv BHK hlwb yog 0.2 thiab 0.03 ug/ml. Kho tus kab mob tiv thaiv kab mob nas thiab FA thiab VA (twv, 5.5 hnub) txo qhov kev faib ua feem nrog erythema los ntawm 100 % rau 24 |^ thiab 38 %, thiab tshem tawm pob ntseg tuag tes tuag taw, mob pob ntseg (vesicles, thiab lwm yam) thiab tuag. Tus kab mob tsis nyob ntawm pob ntseg thiab lub hlwb los ntawm hnub 6, tab sis rov tshwm sim tom qab tsis ua haujlwm hauv cov nas kho nrog VA.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: valacyclovir hydrochloride cas 124832-27-5, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

• Tug: Ribavirin CAS 36791-04-5
• Tom ntej: D-Glucurone CAS 32449-92-6