Thailanstatin A CAS 1426953-21-0

Product Description:

Khoom npe: Thailanstatin A CAS NO: 1426953-21-0

Synonyms:

(3R,5S,7R,8R)-7-{(1E,3E)-5-(2S,3S,5R,6R)-5-{(2Z,4S)-4-(acetyloxy)pent -2-enoylamino}-3,6-dimethyltetrahydro-2H-pyran-2-yl-3-methylpenta-1,3-dien-1-yl}-8-hydroxy-1,6-dioxaspiro2.5oct-5-ylacetic kua qaub;

1,6-Dioxaspiro2.5octane-5-aceticacid,7-(1E,3E)-5-(2S,3S,5R,6R)-5-(2Z,4S) )-4-(acetyloxy)-1-oxo-2-penten-1-ylaminotetrahydro-3,6-dimethyl-2H-pyran-2-yl-3-methyl-1,3-pentadien-1-yl-8- hydroxy-, (3R,5S,7R,8R)-;

Chemical Physical Properties:

Cov tsos mob: Cov hmoov hmoov

Assay: Ntau dua lossis sib npaug rau 99.0 feem pua

Thailanstatin A, uas yog ib qho kev cog lus zoo rau kev tshawb nrhiav tshuaj thiab kev txhim kho, yog muab los ntawm Thailandensis burkholderia MSMB43. Nws nthuav tawm tsawg nanomolar rau subnanomolar cytotoxicity tawm tsam ntau hom kab mob qog noj ntshav hauv tib neeg.

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding "linker-less" ADC.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom raws li patent yog muab rau RD lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: thailanstatin a cas 1426953-21-0, tuam ntxhab, lwm tus muag khoom, Hoobkas, yuav, hauv Tshuag

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