Sitagliptin Phosphate CAS 654671-78-0

Khoom Piav Qhia

Cov Khoom Npe: Sitagliptin Phosphate CAS TSIS: 654671-78-0

Txhais:

(3 R) - 3 - Amino - 1 - (3 - (trifluoromethyl) -5,6-dihydro [1, {{7} }, {{{{{{20 20} 9}} {{{20 "} 9}} 5},}}}}] triazolo [{{{20-x} 20} }} {{{{{20 {xev 20} 9, 5}}}, {}, 3 - a] pyrazin-7 ({{{{{20 "} 9}} {{{ 1 9}} 5}}}}} H) -yl] - {{{{{20 {} 20}}}} {{{20-9 9}} 5}}}} }} - (2, {{{{20 {} 20}} 9}} {{{{20 {} 9}} 5, tr}}},, 5-trifluorophenyl) - { {6}} - butanone phosphate (1: 1);

{{2 1}, - Butanone, {{{{2 1}} 9}} - amino - {{2 1}, - [{{{{{2 1}} 9}}}}, 6-dihydro - {{{{2 1}, 9}} - (trifluoromethyl) - {{2 1}}, {{ 7}}, 4 - triazolo [4, {{{{2 1, 9}} - a] pyrazin-7 ({{{2 1 }} {{{{2 1}, 5}}}} H) -yl] - 4 - (2, 4, {{{ 2 1}} 9}}}} - - trifluorophenyl) -, ({{{{2 1} 9}} R) -, phosphate ({{2 1}} : {{2 1}));

(3 R) - 3 - amino - 1 - [3 - (trifluoromethyl) -5,6-dihydro [1, {{7} }, {{{{{{20 20} 9}} {{{20 "} 9}} 5},}}}}] triazolo [{{{20-x} 20} }} {{{{{20 {xev 20} 9, 5}}}, {}, 3 - a] pyrazin-7 ({{{{{20 "} 9}} {{{ 1 9}} 5}}}}} H) -yl] - {{{{{20 {} 20}}}} {{{20-9 9}} 5}}}} }} - (2,, {{{{20 {} 20}} 9}} {{{{20 {} 9}} 5-trifluorophenyl) butan- 1 - ib phosphate (1: 1);

Tshuaj& Lub cev nqaij daim tawv

Zog: dawb khoom

Ntsuas: ≥ 99. 0%

Lub Hauv Boiling Point: 529. 9 ℃

Flash Point: 274. 3 ℃

Melting Point: 202-204 ℃

Sitagliptin phosphate yog dipeptidyl peptidase D (DDP-4) inhibitor chav kawm ntawm cov tshuaj tsim los ntawm lub tuam txhab German Merck thiab thawj zaug tau txais kev pom zoo ntawm Asmeskas Cov Khoom Noj thiab Tshuaj Siv rau kev kho mob ntshav qab zib {{1}} ntshav qab zib, yog qhov tshiab tshuaj tiv thaiv kab mob, tuaj yeem txhim kho lub cev' tus kheej muaj peev xwm txo cov ntshav siab cov ntshav qabzib ntau dua, thiab qhov feem ntau nce nce ntxiv los ntawm qhov ua kom tsis haum los ntawm qhov ua kom muaj enzyme no, suav nrog cov qib ntawm glucagon-zoo li peptide {{ 4}} thiab glucose-dependant insulinotropic peptide, yog li ua rau tus txiav txim siab txhawm rau txhim kho insulin ntau lawm thiab nres cov piam thaj hauv siab, thiab thaum kawg txo cov kev kho mob hauv cov ntshav siab. Cov yam ntxwv ntawm cov khoom no yog txhawm rau tshuaj insulin secretion, tib lub sijhawm tuaj yeem txo kev tshaib plab, tab sis tsis ua kom yuag, thiab tseem tsis tuaj yeem tshwm sim hypoglycemia thiab edema, tsis tsim nyog siv rau cov neeg mob ntshav qab zib tsis zoo glycemic tswj thiab feem ntau tsim hypoglycemia. Los ntawm kev txheeb xyuas cov chaw kho mob {{{1, 1}}}} kis mob ntawm yam me-rau hom {{1}} mob ntshav qab zib, noj ib hnub ib zaug Sitagliptin phosphate, ib zaug ib zaug {{ 8}} mg, tom qab noj cov tshuaj rau 12 lub lis piam, tuaj yeem ua rau glycated hemoglobin txo 0. {{1 1}}% - 1. {{13} }%. Qhov tshwm sim ntawm kev phiv tshuaj yog zoo ib yam li cov tshuaj placebo, feem ntau pom tias qhov tshwm sim tsis zoo (tshwm sim> 5% thiab ntau dua cov placebo) yog txhaws lossis los ntswg, thiab mob caj pas, mob ntsws ua pa thiab mob taub hau.

Cov kev tshawb fawb soj ntsuam pom tias Sitagliptin phosphate raws li kev kho mob ntshav qab zib hauv cov neeg mob ntshav qab zib hom 2 mob ntshav qab zib, tuaj yeem ua rau glycated hemoglobin (HbA 1 c) ntau ntau txo. Thaum muaj kev sib xyaw nrog cov tshuaj metformin lossis TZDs, muaj lub luag haujlwm tseem ceeb ntawm kev kho cov khoom txuas, tuaj yeem tsom rau peb yam kev ua txhaum loj ntawm hom 2 mob ntshav qab zib: insulin tsis kam, β-cell teeb meem (txo qis ntawm insulin tso), thiab α -Raus tsis ua hauj lwm (tsis tau txhawb nqa hepatic qabzib tiam) ua lub luag haujlwm. Tab sis cov tshuaj yuav tsum tsis txhob siv rau kev kho mob rau cov neeg mob uas muaj hom 1 mob ntshav qab zib lossis ntshav qab zib ketoacidosis.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: sitagliptin phosphate cas 654671-78-0, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: (R) -Phenylalanine CAS TSIS: 673-06-3
• Tom ntej: Tert-butyl 4- (diethoxymethyl) benzyl (methyl) carbamate CAS 1428935-48-1