Rosuvastatin Calcium CAS 147098-20-2

Khoom Piav Qhia:

Khoom Lub Npe: Rosuvastatin Calcium CAS TSIS TAU: 147098-20-2

Lub ntsiab lus:

(3R, 5S, 6E) -7- [4- (4-Fluorophenyl) -6- (1-methylethyl) -2- [methyl (methylsulfonyl) amino] -5-pyrimidinyl] -3,5-dihydroxy-6- heptenoic Acid Calcium ntsev;

Rosuvastatin Calcium ntsev;

Rosuvastatin Hemicalcium;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Dawb mus rau dawb-dawb crystalline Khoom

Kev Ntsuas: ≥99.00%

Kub Point: 745.6 ℃ ntawm 760 mmHg

Cov ntsiab lus melting: 122 ℃

Flash Point: 404.7 ℃

Cov xwm txheej cia: -20 ℃ Lub freezer

Cov Ntaub Ntawv Kev Nyab Xeeb:

HS Code: 2935009090

Rosuvastatin Calcium ntsev yog xaiv, sib tw HMG-CoA reductase inhibitor.

Rosuvastatin Calcium yog kev sib tw inhibitor ntawm HMG-CoA reductase nrog IC50 ntawm 11 nM. IC50 Tus Nqi: 11 nM Lub Hom Phiaj: HMG-CoA reductasein vitro: Rosuvastatin yog cov tshuaj hydrophilic thiab yog qhov xaiv tau zoo rau cov kab mob siab; nws txoj kev nqus tau los nruab nrab los ntawm lub siab tshwj xeeb cov organic anion transporter OATP-C. Rosuvastatin yog qhov muaj kev sib haum xeeb siab rau OATP-C nrog kev sib koom ua ke tsis tu ncua ntawm 8.5 μM. Rosuvastatin inhibits cov roj cholesterol biosynthesis hauv nas lub siab cais hepatocytes nrog IC50 ntawm 1.12 nM. Rosuvastatin ua rau kwv yees li 10 npaug ntau dua ntawm mRNA ntawm LDL receptors ntau dua li pravastatin [1]. Rosuvastatin (100 μM) txo qis ntawm U937 adhesion rau TNF-α-stimulated HUVEC. Rosuvastatin inhibits cov kab lus ntawm ICAM-1, MCP-1, IL-8, IL-6, thiab COX-2 mRNA thiab qib protein los ntawm kev txwv tsis pub c-Jun N-dav hlau kinase thiab nuclear factor-kB hauv endothelial cells.in vivo : Rosuvastatin (3 mg/kg) kev tswj hwm niaj hnub rau 14 hnub txo cov qib roj cholesterol los ntawm 26% hauv cov txiv neej beagle aub nrog cov qib roj cholesterol. Hauv cynomolgus liab, Rosuvastatin txo cov qib roj cholesterol los ntawm 22%. Rosuvastatin (20 mg/kg/hnub) kev tswj hwm rau 2 lub lis piam, ua rau txo qis qis lipoproteins (VLDL) hauv cov nas mob ntshav qab zib mellitus vim Streptozocin. Rosuvastatin qhia pom cov teebmeem antiatherothromhotic hauv vivo. Rosuvastatin (1.25 mg/kg) ua rau muaj kev cuam tshuam ntau heev los ntawm thrombin-induced transmigration ntawm monocvtes hla mesenteric venules ntawm kev tiv thaiv ntawm qhov kawg ntawm tes ntawm tes qhia P-selectin, thiab ua rau nce qib hauv qab ntawm nitric oxide hauv ntu aortic los ntawm 2-zaug.

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Cim npe nrov: rosuvastatin calcium cas 147098-20-2, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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