Ritonavir CAS TSIS: 155213-67-5

Khoom Piav Qhia

Khoom npe: Ritonavir CAS TSIS TAU: 155213-67-5

Txhais:

Norvir;

Ritonavir;

Liponavir Tub ntxhais;

Ritonavi;

ABT-538;

A-84538 ABT-538 Abbott 84538;

Norvi;

RITONA;

N - [({1}}} S, 4 S, 5 S) - 4 - Hydroxy - 1, 6-diphenyl - {{ 3}} - {[(1, 3-thiazol - 5 - ylmethoxy) carbonyl] amino} hexan - {{1}} - yl] -N - {[({ {1}} - isopropyl - 1, 3-thiazol - 4 - yl) methyl] (methyl) carbamoyl} -L-valinamide;

(1 E, {{1}} S) -N - [({1)}, S, {{{6 {} 6}, S, {{6 } S) - {{5}} - Hydroxy - 5 - {(E) - [hydroxy (1, 3-thiazol - 5 - ylmethoxy) methylene] amino} - 1, 6-diphenyl - {{1}} - hexanyl] - {{{1}} - [(E) - (hydroxy {[({{ 10}}}} - isopropyl - 1, 3-thiazol - {{5}} - yl) methyl] (methyl) amino} methylene) amino] -3-methylbutanimidic acid;

1, 3-Thiazol-5-ylmethyl - [(1 S, 2 S, 4 S) - 1 - benzyl - {{5} ) ) - 1, 3-thiazol - 4 - yl] methyl} carbamoyl) amino] butanoyl} amino) -5-phenylpentyl] carbamate;

Tshuaj& Lub cev nqaij daim tawv

Zog: Cov hmoov dawb dawb lossis yuav luag txhua zaus

Ntsuas: ≥ 99%

Ntu: 1. 239 ± 0. {{{3}} g / cm 3

Lub Hauv Boiling Point: 947 ° C ntawm 760 mmHg

Flash Point: 526. 6 ℃

Melting point: 120-122 ℃

Solubility: DMSO: soluble 10 mg / mL (kev daws teeb meem, ua kom sov)

Norvir tau tsim tawm hauv Tebchaws Yelemees, UK thiab Asmeskas rau kev kho mob ntawm kev kho tus kabmob HIV ua ke nrog kev siv tshuaj tiv thaiv kab mob rau cov kabmob hnoos qeev hauv cov ntaub ntawv khaws tseg 72 hnub los ntawm FDA. Nws yog qhov tshuaj tiv thaiv cov kab mob HIV aspartic protease uas yog qhov tseem ceeb hauv kev ua tiav ntawm propeptide rau hauv cov gag, gag-pol noob khoom thiab cov protease nws tus kheej. Qhov kev txwv no ua rau muaj kev nthuav tawm ntawm cov khoom tsis kis tus kab mob kis tau tus kab mob tsis zoo. Nws muaj peev xwm ntau dua li 500 npaug ntawm kev xaiv ntau dua rau kis aspartic protease dua li tib neeg cov qauv, muaj qhov ncauj zoo ntawm bioavailability thiab tej zaum yuav ua rau kom lub bioavailability ntawm lwm cov protease inhibitors. Ritonavir muaj peev xwm nce CD 4 thiab CD 8 lymphocyte suav ntxiv rau kev txo qis kis RNA. Nws yog ntau yam muaj zog dua li saqunavir thiab sib piv hauv cov peev xwm zidovudine thiab lamivudine.

Ritonivir yog tus kab mob HIV protease inhibitor (EC 50 = 25 nM) uas tseem khis CYP 3 A {{3}}, thawj cytochrome P {{{{5 }}}} 50 isoform uas metabolizes protease inhibitors. Los ntawm CYP 3 Ib qho {{3}} kev txwv tsis pub, ritonivir qis dua tuaj yeem txo cov metabolism ntawm cov kab mob uas ua haujlwm tsis tu ncua los tiv thaiv protease inhibitiors, txhim kho lawv txoj kev nyab xeeb thiab kev ua tau zoo.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov hu rau peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: ritonavir cas tsis yog: 155213-67-5, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

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