Relugolix CAS TSIS TAU: 737789-87-6

Khoom Piav Qhia

Khoom npe: Relugolix CAS TSIS: 737789-87-6

0010010 nbsp;

0010010 nbsp;

Txhais:

TAK-385;

Relugolix;

1- [4- [1 - [(2, 6-difluorophenyl) methyl] -5 - [(dimethylamino) methyl] -3- (6-methoxypyridazin-3-yl) - 2, 4-dioxothieno [2, 3-d] pyrimidin-6-yl] phenyl] -3-methoxyurea;

N- [4- [1 - [({3}}, 6-Difluorophenyl) methyl] -5 - [(dimethylamino) methyl] -1, {{3}}, {{ 8}}, 4-tetrahydro - 3 - (6-methoxy - 3 - pyridazinyl) - {{{{8 {}}}, 4-dioxothieno [{{3} }, 3 - d] pyrimidin-6-yl] phenyl] -N 0010010 # 3 9; -methoxy urea;

0010010 nbsp;

0010010 nbsp;

Tshuaj Txhaum 0010010 amp; Lub cev nqaij daim tawv

Zog: Cov hmoov dawb dawb.

Ntsuas: ≥ 99. 0%

0010010 nbsp;

0010010 nbsp;

Relugolix (INN) (kev loj hlob kev cai lub npe TAK-385) yog qhov tsis yog peptide, muaj qhov ncauj, muaj kev xaiv tsis haum ntawm gonadotropin-tso cov tshuaj hormones receptor (GnRHR) (IC 50 =0. 12 nM ) uas tab tom muaj kev txhim kho rau kev siv tshuaj los ntawm Takeda. Nws yog tam sim no nyob rau theem II kev kuaj mob rau kev kho mob ntawm endometriosis, uterine leiomyoma, thiab mob qog nqaij hlav cancer.

Ib qhov ncauj tswj hwm ntawm relugolix ntawm koob tshuaj 3 mg / kg tau pom tias luteinizing qib tshuaj hormones rau ntau tshaj li 24 teev nyob rau hauv cov haujlwm liab cynomolgus, uas qhia txog lub sijhawm ua haujlwm ntev. Cov tshuaj (80 - 160 mg / hnub) tau pom tias yuav txo qis testosterone kom tsis txaus cov qib castrate rau cov txiv neej nrog kev tswj hwm ib zaug ib hnub. Kev noj tshuaj qis dua (10 - 40 mg / hnub) tau kawm nyob rau hauv kev kho mob ntawm endometriosis thiab uterine leiomyoma kom ua tiav ib feem ntawm kev sib deev hormone tawm. Qhov laj thawj ntawm qee qhov kev cuam tshuam rau cov kev mob no yog kom txo qis ntawm qhov tshwm sim thiab qhov mob ntawm cov tsos mob ntawm lub cev lawm xws li kub lub cev thiab kom tsis txhob muaj pob txha ntxhia hloov pauv los ntawm cov tshuaj estrogen uas tuaj yeem ua rau txha osteoporosis.

0010010 nbsp;

0010010 nbsp;

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

0010010 nbsp;

0010010 nbsp;

Cov khoom hauv qab patent yog muab rau R 0010010 amp; D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

0010010 nbsp;

Cim npe nrov: relugolix cas no: 737789-87-6, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: Ethyl 2 - ((2, 6-difluorobenzyl) (ethoxycarbonyl) amino) -4-methyl-5- (4-nitrophenyl) thiophene-3-carboxylate CAS 308831-94-9
• Tom ntej: 3, {{{{8 {} 16}}, {{{{16 {} 16}}}, {{{{{16 {} 16} hwv h V fb. }}}} 2}}}}} a-Tetrahydro-7- (phenylmethoxy) - 1 H - [1, {{1}}] oxazino [{ {0}}, {{{8 "}}} - c] pyrido [{{{1 4,} 2},, 1 - f] [{ 8}},, {{{{1 4}}, {{15 {}}}, {{1},] {{{{8 {}}}] triazine-6,8-dione CAS 1 {{0 }} 70 {{{{1 {{16)}}} 2}} 50 - 3 9-7