(R) -6- (2-fluorophenyl) -N- (3- (2-((2-methoxyethyl) amino) ethyl) phenyl) -5,6-dihydrobenzo [h] quinazolin-2-amine CAS 1234356-69 -4

Khoom Piav Qhia:

Khoom Lub Npe:

(R) -6- (2-fluorophenyl) -N- (3- (2-((2-methoxyethyl) amino) ethyl) phenyl) -5,6-dihydrobenzo [h] quinazolin-2-amine CAS TSIS TAU: 1234356 -69-4

Lub ntsiab lus:

Derazantinib;

Derazantinib (ARQ-087);

ARQ-087; ARQ087;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Khoom los yog hmoov

Kev Ntsuas: ≥98.0%

Ceev: 1.218 ± 0.06 g/cm3 (Kwv yees)

Kub Npau Suav: 615.1 ± 65.0 ℃ (Kwv yees)

PKa: 9.04 ± 0.19 (kwv yees)

Flash Point: 325.8 ± 34.3 ℃

Vapor Siab: 0.0 ± 1.8 mmHg ntawm 25 ℃

Index ntawm Refraction: 1.632

Derazantinib (ARQ-087) yog ATP kev sib tw tyrosine kinase inhibitor; nthuav tawm cov haujlwm muaj zog tiv thaiv FGFR1-3 chondrocytes nrog IC50s ntawm 4.5, 1.8, thiab 4.5 nM, feem. ARQ-087, tseem hu ua Derazantinib, yog qhov ncauj fibroblast kev loj hlob tau txais (FGFR) inhibitor nrog cov cuab yeej antitumor. FGFR ua lub luag haujlwm hauv kev tswj hwm tus cwj pwm tseem ceeb ntawm tes suav nrog kev nthuav dav, kev sib txawv ntawm tes thiab lwm yam. FGFR kev txwv tsis raug suav tias yog tus tsav tsheb hauv ntau yam mob qog noj ntshav. ARQ 087 khi rau FGFR thiab tiv thaiv kev ua kom zoo ntawm FGFR yog li tuaj yeem tiv thaiv kev tsim cov qog nqaij hlav thiab kev loj hlob ntawm qog.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: (r) -6- (2-fluorophenyl) -n- (3- (2-((2-methoxyethyl) amino) ethyl) phenyl) -5,6-dihydrobenzo [h] quinazolin-2-amine cas 1234356-69 -4, cov chaw tsim khoom, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

• Tug: R428 (BGB324) CAS 1037624-75-1
• Tom ntej: AZD-7594 CAS 1196509-60-0