Pyrazolo [1,5-a] pyrimidine-3-carboxamide, 7- (3-methylphenyl)-CAS 125079-83-6

Khoom Piav Qhia:

Khoom Lub Npe: Pyrazolo [1,5-a] pyrimidine-3-carboxamide, 7- (3-methylphenyl)-CAS TSIS TAU: 125079-83-6

Lub ntsiab lus:

CU-CPT-8M;

TLR8 INHIBITOR;

CPD1578;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Crystalline khoom

Kev Ntsuas: ≥98.0%

Ceev: 1.35 ± 0.1 g/cm3 (Kwv yees)

PKa: 12.41 ± 0.50 (Kwv yees)

Solubility: DMSO ≥ 22 mg/ml

Cia: ntawm -20 ℃

CU-CPT-8m yog tus tshwj xeeb TLR8 antagonist, nrog IC50 ntawm 67 nM. CU-CPT8m yog tus yeeb ncuab ntawm tus xov tooj zoo li tus txais 8 (TLR8) nrog Kd ntawm 220 nM thiab IC50 ntawm 67 nM hauv kev ntsuas. Kev kho mob ntawm 1 μM CU-CPT-8m tshem tawm qhov ua tiav ntawm TNF-α thiab IL-8 mRNA qib vim R848. CU-CPT-8m inhibits R848-induced TNF-α kev tsim tawm hauv qhov sib txawv ntawm THP-1 monocytes cells hauv kev txhaj tshuaj raws tus yam ntxwv nrog IC50 ntawm 90 ± 10 nM, uas yog pom zoo nrog nws IC50 tus nqi txiav txim siab hauv HEK-Blue TLR8 hlwb.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: pyrazolo [1,5-a] pyrimidine-3-carboxamide, 7- (3-methylphenyl)-cas 125079-83-6, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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