OLTIPRAZ CAS 64224-21-1

Product Description:

Khoom npe: OLTIPRAZ CAS NO: 64224-21-1

Synonyms:

3H-1,2-DITHIOLE-3-THIONE,4-METHYL-5-PYRAZINYL;

4-Methyl-5-pyrazin-2-yl-1,2-dithiole-3-thione;

5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione;

Tshuaj& Lub cev muaj zog:

Cov tsos: Liab Khoom

Kev Ntsuas: ≥99.0%

Qhov ceev: 1.51 g / cm3

Boiling Point: 408.1 ℃ ntawm 760 mmHg

Melting Point: 165-166 ℃

Flash Point: 200.6 ℃

Refractive Index: 1.76

Sensitive: Lub teeb Sensitive

Cov ntaub ntawv kev nyab xeeb:

Cov Lus Qhia Txog Kev Nyab Xeeb: S26; S36/37/39

HS Code: 2933990090

Cov nqe lus pheej hmoo: R36/37/38

Oltipraz yog ib qho hluavtaws, hloov 1,2-dithiole-3-thione yav dhau los siv hauv tib neeg los ua tus neeg sawv cev antischistosomal. Cov kev tshawb fawb tsiaj tau pom tias oltipraz yog ib qho muaj zog inducer ntawm Phase II detoxification enzymes, tshwj xeeb tshaj yog glutathione-S-transferase (GST). Oltipraz tam sim no paub tias siv rau kev tiv thaiv qog nqaij hlav.

Oltipraz muaj cov nyhuv inhibitory ntawm HIF-1α ua kom los ntawm insulin nyob rau lub sijhawm, ua tiav HIF-1α induction ntawm ≥10 μM concentrations, IC50 ntawm Oltipraz rau HIF-1α inhibition yog 10 μM.IC50 tus nqi: 10 μMTarget: HIF-1αin vitro: Oltipraz inhibits HIF-1α kev ua haujlwm thiab HIF-1α-nyob ntawm cov qog loj hlob, uas tuaj yeem tshwm sim los ntawm qhov txo qis hauv HIF-1α ruaj khov los ntawm S6K1 inhibition ua ke nrog H2O2-scavenging nyhuv. Kev kho Oltipraz kuj inhibits HIF-1α ua kom txhawb nqa los ntawm hypoxia lossis CoCl2. Oltipraz yog ib qho tshuaj tiv thaiv kab mob qog noj ntshav thiab muaj cov nyhuv inhibitory ntawm angiogenesis thiab qog loj hlob. Oltipraz kuj yog ib qho kev sib tw inhibitor ntawm no cytochrome P450, nrog qhov pom tseeb Ki ntawm 10 μM. hauv vivo: Hauv cov nas qus, qib siab ntawm mRNA rau tag nrho cov noob tshuaj ntsuam xyuas tau nce ntxiv tom qab kev kho Oltipraz, nrog qhov nce siab tshaj plaws (kho / tswj) rau NQO1 mRNA qib (7.6-fold). Northern blot soj ntsuam pom tau hais tias qhov pom tau nce hauv GST thiab NQO1 cov haujlwm los ntawm Oltipraz hauv cov nas qus tau ua ntej los ntawm kev nce siab hauv RNA qhia. Interestingly, mRNA qib ntawm Nrf2 nws tus kheej tau nce ntau dua 3-fold los ntawm kev kho Oltipraz.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom raws li patent muaj rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: oltipraz CAS 64224-21-1, tuam ntxhab, lwm tus muag khoom, Hoobkas, yuav, hauv Tshuag

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