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Hu rau:Errol Zhou (Mr.)

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APIs thiab Intermediates
Nirmatrelvir, PF -07321332 CAS 2628280-40-8

Nirmatrelvir, PF -07321332 CAS 2628280-40-8

CAS Nr: 2628280-40-8
Cov mis mos molecular: C23H32F3N5O4
Molecular Luj: 499.53
EINECS NO:605-001-5
MDL NO.: N/A

Txhawb tshuaj

Product Description:

Khoom npe: Nirmatrelvir, PF-07321332 CAS 2628280-40-8

 

Synonyms:

Nirmatrelvir (PF{0}});

PF07321332(Paxlovid);

(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin{{10}}yl]ethyl]{ {11}}[(2S)-3,3-dimethyl-2-[(2,2,{18}}trifluoroacetyl)amino]butanoyl]-6,{{ 20}}dimethyl-3-azabicyclo[3.1.0]hexane{25}}carboxamide;

 

Chemical & Physical Properties

Cov tsos mob: Cov hmoov hmoov

Kev Ntsuas: 99% +

Kub taw tes: 742.4 ± 6 0.0 degree

Solubility: DMSO: 140 mg / mL (280.26 mM; Xav tau ultrasonic)

Qhov ceev: 1.267 ± {2}}.06 g / cm3

Pka:10.26 ± 0.46

 

Daim ntawv thov

Paxlovid yog ib qho tshuaj tua kab mob sib xyaw ua ke ntawm ob ntsiav tshuaj.Ib ntsiav tshuaj yog Nirmatrelvir (150mg), ib qho inhibitor ntawm 3CL protease (tseem hu ua lub ntsiab protease, Mpro) ntawm tus tshiab coronavirus.3CL protease yog ib qho tseem ceeb protease uas hydrolyzes polymeric precursor proteins. encoded los ntawm RNA los tsim cov proteins ua haujlwm thaum muaj tus kabmob coronavirus. Nematavir tuaj yeem tiv thaiv SARS-CoV-2 coronavirus replication los ntawm inhibiting 3CL protease; Lwm cov ntsiav tshuaj yog Ritonavir (100mg), HIV-1 protease inhibitor thiab CYP3A4 (cytochrome P450 3A4 enzyme) inhibitor .

 

 

 

 

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

 

 

Cov khoom raws li patent yog muab rau R & D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: nirmatrelvir,pf-07321332 cas 2628280-40-8, tuam ntxhab, lwm tus muag khoom, Hoobkas, yuav, hauv Tshuag

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