Mefloquine HCl CAS 51773-92-3

Khoom Qhia:

Khoom npe: Mefloquine HCl CAS TSIS TAU: 51773-92-3

Txhais:

2,8-bis (trifluoromethyl) -alpha-2-piperidinyl-4-quinolinemethanomonohydroch;

dl-erythro-alpha- (2-piperidyl) -2,8-bis (trifluoromethyl) -4-quinolinemethanol; s *) - (r (+ -) - lorid;

Mefloquin hydrochloride;

Tshuaj& Cov Khoom Uas Lub Cev:

Tsos: Off-dawb rau daj khoom

Ntsuas: ≥99%

Qhov ceev: 1.383g / cm3

Lub Ntsiab Kub: 415.7 ℃ ntawm 760mmHg

Melting Point: 250-254 ℃

Flash Point: 205.2 ℃

Qhov Ruaj: Ruaj nyob rau qub thiab nias

Cia Kev Mob: Khaws tsuas yog nyob hauv qhov qub. Muab lub taub ntim kaw ntom.

Dej Solubility: DMSO: 38 mg / mL, soluble

Cov Ntaub Ntawv Kev Nyab Xeeb:

RTECS: VC0308000

WGK Lub Teb Chaws Yelemees: 3

Cov Lus Tseem Ceeb: R22

Txoj Cai Kev Nyab Xeeb: Xn

Lub Cim: GHS07

Kos Npe: Lo Lus Ceeb Toom

Cov Lus Tshaj Tawm: H302

Cov ntawv ceeb toom ua ntej: P301 + P312 + P330

Mefloquine hydrochloride yog tshuaj loog quinoline antimalarial uas muaj kev cuam tshuam nrog cov tshuaj tiv thaiv kab mob antimrhythmic tus sawv cev quinidine. Tus nqi IC50: 1 microM (rau K + channel) Lub Hom Phiaj: AntiparasiticMefloquine yog siv dav hauv kev kho mob thiab prophylaxis ntawm Plasmodium falciparum malaria. MQ tuaj yeem tsim kev mob siab oxidative hauv vitro. Cov ntaub ntawv pov thawj qhia tias cov tshuaj tiv thaiv cov pa oxygen (ROS) yuav siv los ua cov tshuaj tua kabmob los tua cov kabmob kheesxaws [2]. Mefloquine ua rau qeeb ntawm kev ua kom muaj zog ntawm KvLQT1 / minK thiab ntau qhov kev thaiv tau pom tseeb ntawm qis dua cov peev txheej piv nrog ntau dua. HERG channel dej ntws tau txog 6-ntu tsis rhiab los thaiv mefloquine (IC50=5.6 microM). Thaiv ntawm HERG tso tawm kom pom qhov muaj qhov cuam tshuam zoo nrog qhov siab tshaj plaws tau txais ntawm ntau qhov chaw muaj peev xwm [1]. MQ muaj qhov kev xaiv tshwj xeeb cytotoxicity uas inhibits PCa kev loj hlob ntawm tes. MQ-mediated ROS ib txhij downregulated Akt phosphorylation thiab qhib cov teeb meem ua suab nrov tshaj lub cim kinase (ERK), c-Jun N-terminal kinase (JNK) thiab adenosine monophosphate-activated protein kinase (AMPK) cov paib hauv PC3 hlwb. hauv vivo: nas cev xeeb tub tau kho qhov ncauj nrog AS (15 thiab 40 mg / kg lub cev hnyav (bwt) / hnub), MQ (30 thiab 80 mg / kg bwt / hnub) thiab AS / MQ (15/30 thiab 40/80) mg / kg bwt / hnub) hnub 9-11 post coitum (pc). Cov pas dej tau txhim kho nyob rau hnub 12 pc thiab kev siv tes taw thiab embryos keeb kwm kev ntsuas tau raug soj ntsuam.Peb kev sim: kev ua ntawm Mefloquine tawm tsam urist Schistosomiasis.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: mefloquine hcl cas 51773-92-3, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

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