Marizomib CAS 437742-34-2

Product Description:

Khoom npe: Marizomib CAS NO: 437742-34-2

Synonyms:

(-)-SalinosporaMide A;

SalinosporaMide A;

Marizomib (Salinosporamide A);

Chemical Physical Properties:

Tsos: Dawb rau beige hmoov

Assay: Ntau dua lossis sib npaug rau 99.0 feem pua

Density: 1.348±0.06 g/cm3(Predicted)

Melting Point: 168-170 degree

Boiling Point: 547.0±50.0 degree (Predicted)

Cia kub: -20 degree

Pka: 13.10±0.20(Predicted)

Cov ntaub ntawv kev nyab xeeb:

PIB: RN6803500

Salinosporamide A yog ib qho muaj zog proteasome inhibitor tau kawm raws li tus neeg sawv cev tiv thaiv kab mob. Nws nkag mus rau theem I tib neeg kev sim tshuaj rau kev kho mob ntawm ntau yam myeloma, tsuas yog peb xyoos tom qab nws tshawb pom hauv 2003. Cov khoom lag luam marine no yog tsim los ntawm obligate marine kab mob Salinispora tropica thiab Salinispora arenicola, uas muaj nyob rau hauv dej hiav txwv sediment. Salinosporamide A belongs rau tsev neeg ntawm cov tebchaw, paub sib sau ua salinosporamides, uas muaj cov haujlwm ua haujlwm hnyav -lactam- -lactone bicyclic core. Marizomib (Salinosporamide A) yog thib ob - tiam, irreversible, hlwb - penetrant, pan-proteasome inhibitor. Marizomib inhibits CT-L (5), CT-T-laspase-zoo li (C-L, 1) thiab trypsin{13} }zoo li (T-L, 2) kev ua ub no ntawm 20S proteasome (IC50=3.5, 28, thiab 430 nM, feem).

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom raws li patent yog muab rau RD lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: marizomib cas 437742-34-2, tuam ntxhab, lwm tus muag khoom, Hoobkas, yuav, hauv Tshuag

• Tug: Brefeldin A CAS 20350-15-6
• Tom ntej: Staurosporine CAS 62996-74-1