Hu rau:Errol Zhou (Mr.)
Tel: ntxiv 86-551-65523315
Mobile/WhatsApp: ntxiv 86 17705606359
QQ:196299583
Skype:lucytoday@hotmail.com
Email:sales@homesunshinepharma.com
Ntxiv:1002, Huanmao Tsev, No.105, Mengcheng Txoj kev, Hefei Lub zos, 230061 Tuam Tshoj
CAS TSIS TAU: 1454846-35-5
Cov Qauv Nqaij: C21H19FN6O2
Molecular Luj: 406.41300
EINECS TSIS MUAJ: 813-704-5
MDL TSIS TAU: NA
Khoom Qhia:
Khoom npe: Lorlatinib CAS TSIS: 1454846-35-5
Txhais:
PF 06463922;
PF-06463922 Lorlatinib;
Tshuaj& Cov Khoom Uas Lub Cev:
Tsos: Dawb rau off-dawb khoom
Ntsuas: ≥98.0%
Qhov ceev 1.42 ± 0.1 g / cm3 (Kev kwv yees)
Cov ntsiab lus npau npau: 675.0 ± 55.0 Pred (Xav Tau)
Cia: -20 ℃
Kev ruaj khov: ≥ 2 xyoos
Pka: 6.05 ± 0.40 (Teem Tau)
Cov Ntaub Ntawv Kev Nyab Xeeb:
Kos Npe: Lo Lus Ceeb Toom
Cov Khoom Siv Kev Nyab Xeeb: H302
Cov ntawv ceeb toom: P280-P305+P351+P338
Khaws Condiiton: Hmoov -20 ℃ 3 xyoos 4 ℃ 2 xyoos; Hauv qhov hnyav -80 ℃ 6 hlis -20 ℃ 1 hlis
Lorlatinib (PF-06463922) yog ib cov tshuaj tshiab hauv kev tsim kho rau pawg ncua ntawm cov neeg tsis muaj mob qog nqaij hlav hauv hlwb tsawg yog ALK lossis ROS1 zoo thiab tau dhau los kho cov tshuaj kho mob nrog hom tshuaj uas yog hom mob cancer.Lorlatinib tam sim no tau raug soj ntsuam hauv Kev Tshawb Fawb Qib II raws li kev noj tshuaj ntawm qhov ncauj ntawm 100 mg txhua hnub. Yog tias muaj kev ua lag luam nws yuav dhau los ua kev kho mob rau cov pab pawg neeg ALKor ROS1 zoo.
Lorlatinib ua los ntawm inhibiting ALK thiab ROS1 receptor tyrosine kinases, nrog cov haujlwm muaj zog tiv thaiv qhov dav ntawm ALK tiv taus kev hloov pauv. Los ntawm inhibiting ALK phosphorylation thiab ROS1 kev ua haujlwm, lorlatinib inhibits qhov kev nqes tes qis, yog li ua rau cov txheej txheem apoptosis, uas ua rau muaj kev txwv tsis pub cov qog hlwb loj hlob.
Vim tias cov qog ua haujlwm nyuaj thiab txhim kho txoj kev tiv thaiv kev kho mob, kev hloov kho kab mob yog qhov nyuaj rau cov neeg mob uas muaj ALK-zoo metastatic tsis mob cell tsis txaus ntsws (NSCLC). Ib qho chaw qhia dav dav ntawm kev hloov pauv hauv metastatic NSCLC yog lub hlwb.
Lorlatinib tau tsim tshwj xeeb tsim los tiv thaiv kev hloov cov qog uas ua kom lub cev tsis kam mus rau lwm cov tshuaj tiv thaiv ALK thiab kom nkag mus rau cov ntshav ntawm lub hlwb.
Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!
Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.
Cim npe nrov: lorlatinib cas 1454846-35-5, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag
