Leptomycin B CAS 87081-35-4

Product Description:

Khoom npe: Leptomycin B CAS NO: 87081-35-4

Synonyms:

Leptomycin B,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-(2S,3S)-3,6-Dihydro-3-methyl-6-oxo -2H-pyran-2-yl-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoicacid;

2,10,12,16,18-nonadecapentaenoic acid;

7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5;

Chemical Physical Properties:

Cov tsos mob: Dawb crystalline khoom

Assay: Ntau dua lossis sib npaug rau 99.0 feem pua

Qhov ceev: 1.072 g / cm3

Boiling Point: 725.8 degree ntawm 760 mmHg

Melting Point: 41-44 degree

Flash Point: 224.7 degree

Refractive Index: 1.542

Cia txias: -20 degree

Cov ntaub ntawv kev nyab xeeb:

Cov Lus Qhia Txog Kev Nyab Xeeb: 7-16-24-33-45

HS Code: 2916190090

RIDADR: UN 1230 3

Risk Nqe: R23/25

Cov Codes Hazard: T; F

Leptomycin B yog cov metabolite thib ob uas tsim los ntawm Streptomyces spp.

Leptomycin B (LMB) yog thawj zaug tshawb pom los ua ib qho tshuaj tiv thaiv kab mob -cov kab mob fungal. Leptomycin B tau pom tias ua rau cov cell elongation ntawm fission poov xab Schizosaccharomyces pombe. Txij thaum ntawd los no cov nyhuv elongation tau siv rau bioassay ntawm leptomycin. Txawm li cas los xij, cov ntaub ntawv tsis ntev los no qhia tau hais tias Leptomycin ua rau G1 cell voj voog raug ntes nyob rau hauv mammalian hlwb thiab yog ib tug muaj zog tiv thaiv - qog nqaij hlav tawm tsam murine sim qog nyob rau hauv kev kho mob ua ke.

Leptomycin B has been shown to be a potent and specific nuclear export inhibitor in human and the fission yeast Schizosaccharomyces pombe. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1 (XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence (NES), by glycosylating a cysteine residue (cysteine 529 in S. pombe). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it inhibits the inactivation of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

Leptomycin A (LPA) tau tshawb pom ua ke nrog LMB. LMB yog ob npaug zog li LPA.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom raws li patent yog muab rau RD lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: leptomycin b cas 87081-35-4, tuam ntxhab, lwm tus muag khoom, Hoobkas, yuav, hauv Tshuag

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