Lamivudine Salicylate CAS 173522-96-8

Khoom Piav Qhia:

Khoom Lub Npe: Lamivudine salicylate CAS TSIS TAU: 173522-96-8

Lub ntsiab lus:

2r- (Hydroxymethyl) -5 (S) -Cytosin-1-Yl-1,3-Oxathiolanesalicycic Acid ntsev;

2R- (hydroxymethyl) -5 (s) -cytosin-1-yl- [1,3] -oxathiolane salicylic acid ntsev (nruab nrab ntawm lamivudine);

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Dawb mus rau dawb-dawb rau lub teeb daj hmoov

Kev Ntsuas: ≥99.00%

Qhov tseeb Mass: 367.083801

Melting Point: 138-143 ℃

Cov Ntaub Ntawv Kev Nyab Xeeb:

Lo Lus Teeb: Ceeb Toom

Cov Lus Qhia Teeb Meem: H315; H319; H335

Cov lus ceeb toom ceev faj: P261; P264; P271; P280; P302+P352; P304+340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+233; P405; P501

Lamivudine yog ib yam khoom siv tshuaj kws kho mob uas muaj cov tshuaj tua kab mob zoo, uas yog siv los tiv thaiv kab mob siab B thiab tiv thaiv kab mob HIV. Nws yog lub luag haujlwm tseem ceeb hauv kev kho kab mob cocktail tam sim no rau kab mob siab B thiab AIDS. Nws cov synthesis yuav tsum tau siv ntau dhau ntawm cov tshuaj nruab nrab. Lamivudine intermediate HDMS lamivudine salicylate molecular formula: C15H17O6n3S.H2O, nws lub npe tshuaj: (2R-cis) -4-amino-1-(2-hydroxymethyl-1, 3-oxythiacyclo-pentyl) -1H-pyridine-2-ketone salicylate . Nyob rau hauv tus txheej txheem ntawm lamivudine intermediate synthesis, cov ntaub ntawv pej xeem hauv tsev thiab txawv teb chaws. Txoj hauv kev tshaj tawm los ntawm Tebchaws Meskas daim ntawv pov thawj yog siv 2-bromodiethoxyethane ua raw khoom, ua haujlwm nrog thiobenzoic acid thiab tom qab ntawd hydrolysis nrog sodium hydroxide kom tau 2-chemicalbook diethoxyethane, ua haujlwm nrog benzoyl oxy acetaldehyde kom tau 2-benzoyl oxy methyl 5-ethoxy -1, 3-oxy thiacyclopentane, tom qab ntawd catalyze nrog trifluoromethylate trimethyl silane. Cov tshuaj tiv thaiv nrog cytosine tiv thaiv los ntawm trimethylsilane, acetylation, kem chromatography kom tshem tawm lub cev trans, deacetylation kom tau txais cov khoom cis; Acetylation ntawm cis cov khoom tsim cov kua qaub thiab tshuaj chlorine menthol ester cov tshuaj tiv thaiv, rov tsim dua tshiab cais (2 r, 5 s) isomer, ammonia daws rau lamivudine, txoj kev 2 rau ryukyu thiab puag 2 ethoxy ethane cov tshuaj tiv thaiv nrog benzoyl oxygen acetaldehyde rau 2 - methyl benzoyl oxygen - 5 - ethoxy - 1, 3 - oxygen heterocyclic sulfur pentane cov tshuaj tiv thaiv tawm los qis, cov khoom siv raw rau txoj, tseem yuav tsum tau tshem lub cev trans, Qhov tshwm sim yog tias cov txiaj ntsig tau raug txo qis, tus nqi nce, thiab kev siv chromatography kem tsis zoo rau kev tsim khoom lag luam.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: lamivudine salicylate cas 173522-96-8, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

• Tug: (1R, 2S, 5R) -Menthyl- (2R, 5S) -5- (4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3] oxathiolane-2-carboxylic Acid CAS 147027- 10-9
• Tom ntej: (2R, 5R) -5-Hydroxy-1,3-oxathiolane-2-carboxylicacid (1R, 2S, 5R) -5-methyl-2- (1-methylethyl) cyclohexyl Ester CAS 147126-62-3