Ivacaftor (VX-770) CAS TSIS TAU: 873054-44-5

Cov Khoom Qhia:

Khoom npe: Ivacaftor (VX-770) CAS TSIS TAU: 873054-44-5

Txhais:

[14C] -Ivacaftor; Kalydeco;

N- (2,4-ditert-butyl-5-hydroxyphenyl) -4-oxo-1H-quinoline-3-carboxamide;

N- [2,4-bis (1,1-dimethylethyl) -5-hydroxyphenyl] -1,4-dihydro-4-oxoquinoline-3-carboxaraide;

N- [2,4-Bis (tert-butyl) -5-hydroxyphenyl] -1,4-dihydro-4-oxo-3-quinolinecarboxamide;

Tshuaj& Lub cev nqaij daim tawv

Zog: cov hmoov dawb dawb

Ntsuas: ≥98.0%

Qhov ceev: 1.187g / cm3

Lub Ntsiab Kub: 550.4 ℃ ntawm 760 mmHg

Flash Point: 286.7 ℃

Ivacaftor (lub npe lag luam Kalydeco, tsim tawm raws li VX-770) yog cov tshuaj siv los kho cystic fibrosis hauv cov neeg muaj qee yam kev hloov pauv hauv cystic fibrosis transmembrane conductance regulator (CFTR), uas suav txog 4-5% feem ntau ntawm cystic fibrosis, thiab muaj nyob hauv cov tshuaj sib xyaw ua ke, lumacaftor / ivacaftor, uas yog siv los kho cov neeg mob cystic fibrosis uas muaj F508del hloov hauv CFTR.

Ivacaftor tau tsim los ntawm Vertex Pharmaceuticals hauv Cystic Fibrosis Foundation thiab yog thawj cov tshuaj uas kho cov hauv paus tsis yog qhov tsos mob ntawm tus kab mob. Nws tau pom zoo los ntawm FDA nyob rau lub Ib Hlis 2012, thiab tau hu ua" qhov tseem ceeb tshaj plaws tshuaj tshiab ntawm 2012", thiab" cov tshuaj zoo" ;. Nws yog ib qho tshuaj uas kim tshaj plaws, raug nqi ntau tshaj $ 300,000 nyob rau ib xyoo, uas tau ua rau kev thuam ntawm Vertex rau tus nqi siab. Cov tshuaj sib xyaw ua ke tau pom zoo los ntawm FDA thaum Lub Xya Hli 2015.

Cystic fibrosis tshwm sim los ntawm ib qho ntawm ntau qhov kev tsis xws luag hauv CFTR protein, uas tswj cov kua dej hauv cov hlwb thiab cuam tshuam rau cov khoom ntawm lub hws, kua dej hauv plab, thiab cov hnoos qeev. Ib qho kev tsis xws luag yog G551D hloov pauv, nyob rau hauv uas cov amino acid glycine (G) hauv txoj hauj lwm 551 yog hloov nrog aspartic acid (D). G551D yog tus cwj pwm los ntawm kev ua tsis zoo ntawm CFTR protein ntawm lub ntsej muag ntawm tes. Xws li G551D, cov protein raug muag mus rau qhov chaw raug, epithelial cell saum npoo, tab sis ib zaug muaj cov protein tsis tuaj yeem thauj chloride los ntawm cov channel. Ivacaftor, CFF lub zog ua haujlwm, txhim kho kev thauj mus los ntawm chloride los ntawm cov ion channel los ntawm khi rau cov channel ncaj qha mus ntxias cov hom tsis muaj kev sib tw uas tau ua rau muaj qhov tshwm sim ntau dua uas cov channel qhib.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: ivacaftor (vx-770) cas tsis: 873054-44-5, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

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