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Ntxiv:1002, Huanmao Tsev, No.105, Mengcheng Txoj kev, Hefei Lub zos, 230061 Tuam Tshoj
CAS NO: 1644670-37-0
Cov mis mos molecular: C25H30N2O4
Molecular Luj: 422.52
EINECS NO: N / A
MDL Nr.: MFCD32174282
Product Description:
Khoom npe: Iptacopan CAS 1644670-37-0
Synonyms:
{{0}[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1}H-indol-4-}yl methyl]piperidin{10}}yl]benzoic acid;
Chemical & Physical Properties:
Cov tsos mob: dawb mus rau cov hmoov dawb dawb
Assay: Ntau dua lossis sib npaug rau 99.0%
Kub Point: 599.1 degree
Qhov ceev: 1.25g / cm3
Solubility: DMSO:50.0(Max Conc. mg/mL); 118.34 (Max Conc. mM)
Siv
Iptacopan yog ib qho me me-molecule yam B inhibitor yav tas los soj ntsuam raws li ib qho kev kho mob rau cov ntshav tsis tshua muaj kab mob paroxysmal nocturnal hemoglobinuria (PNH) los ntawm inhibiting qhov complement factor B. Factor B yog ib tug zoo regulator ntawm lwm txoj kev ntxiv ntxiv, qhov twg nws activates C3 convertase. thiab tom qab ntawd C5 convertase. Qhov no yog qhov tseem ceeb tshwj xeeb rau PNH, qhov twg ib qho ntawm cov kab mob tseem ceeb yog kev hloov pauv ntawm PIGA noob. Vim qhov kev hloov pauv no, tag nrho cov progeny erythrocytes yuav tsis muaj glycosyl phosphatidylinositol-anchored proteins uas feem ntau thauj tog rau nkoj 2 membrane proteins, CD55 thiab CD59, uas tiv thaiv cov qe ntshav tawm tsam lwm txoj hauv kev ntxiv.
Tsis tas li ntawd, iptacopan muaj cov txiaj ntsig ntawm kev tsom xam B, uas tsuas yog cuam tshuam rau lwm txoj hauv kev ntxiv, tawm hauv txoj hauv kev classic thiab lectin tsis muaj kev cuam tshuam rau lub cev tseem tuaj yeem tiv thaiv lub cev tiv thaiv kab mob.
Thaum Lub Kaum Ob Hlis 6th, 2023, Iptacopan raws li hom npe Fabhalta tau pom zoo los ntawm FDA rau kev kho cov neeg laus nrog PNH. Qhov kev pom zoo no yog ua raws li cov txiaj ntsig tau zoo los ntawm theem III APPL-PNH thiab APPOINT-PNH kev tshawb fawb, qhov twg 82.3% thiab 77.5% ntawm cov neeg mob tau ntsib kev txhim kho hemoglobin tsis tu ncua yam tsis muaj kev hloov pauv.
Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!
Cov khoom raws li patent yog muab rau R & D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.
Cim npe nrov: iptacopan cas 1644670-37-0, manufacturers, lwm tus neeg, Hoobkas, yuav, Tshuag
