Gadopentetate Dimeglumine CAS 86050-77-3

Khoom Piav Qhia:

Khoom Lub Npe: Gadopentetate dimeglumine CAS TSIS: 86050-77-3

Lub ntsiab lus:

2- [bis [2- [carboxylatomethyl (carboxymethyl) amino] ethyl] amino] acetate, gadolinium (3+), (2R, 3R, 4R, 5S) -6- (methylamino) hexane-1,2,3,4 , 5-pentol;

Diethylenetriaminepentaacetic acid dimeglumine ntsev gadolinium chelate;

Meglumine gadopentetate;

Tshuaj& Lub Cev Muaj Zog:

Tsos: Dawb hmoov, tsis hnov ​​tsw

Kev Ntsuas: ≥99.00%

Pawg Loj: 938.260315

Cov Ntaub Ntawv Kev Nyab Xeeb:

Cov ntaub ntawv phom sij txaus ntshai: 86050-77-3 (Cov ntaub ntawv phom sij txaus ntshai)

Toxicity: LD50 iv hauv nas: 10 mmol/kg (Weinmann).

Gadopentetic acid yog ib qho ntawm cov npe lag luam rau gadolinium-based MRI tus neeg sawv cev sib piv, feem ntau yog siv los ua ntsev ntawm qhov nyuaj ntawm gadolinium nrog DTPA (diethylenetriaminepentacetate) nrog cov tshuaj mis A2 [Gd (DTPA) (H2O)]; thaum cation A yog daim ntawv protonated ntawm cov amino qab zib meglumine ntsev mus hauv qab lub npe&"; gadopentetate dimeglumine &"; Nws tau piav qhia nyob rau xyoo 1981 thiab tau qhia ua thawj tus neeg sawv cev sib piv MRI hauv xyoo 1987. Nws tau siv los pab saib xyuas cov hlab ntshav thiab ntawm cov nqaij los yog mob uas cov hlab ntshav dhau los ua&"leaky &"; Nws feem ntau siv thaum saib qhov txhab hauv lub cev nrog cov hlab ntsha txawv txav lossis txawv txav hauv cov ntshav -lub hlwb teeb meem. Feem ntau nws yog txhaj tshuaj txhaj tshuaj. Gd-DTPA raug cais raws li acyclic, ionic gadolinium sib piv nruab nrab. Nws cov khoom siv hluav taws xob txo T1 lub sijhawm so (thiab qee qhov T2 thiab T2* lub sijhawm so) hauv NMR, uas yog lub hauv paus ntawm nws cov chaw kho mob.

Lub raj mis ntawm Magnevist tus neeg sawv cev sib piv.

Ua lag luam raws li Magnevist los ntawm Bayer Schering Pharma, nws yog thawj tus neeg sib piv tshuaj sib xyaw kom muaj rau kev siv tshuaj kho mob, thiab tau siv thoob plaws ntiaj teb. Cov neeg sawv cev sib piv zoo sib xws yog Magnetol tsim los ntawm Soreq, Dotarem (gadoterate) Guerbet, MultiHance (gadobenate dimeglumine) thiab ProHance (gadoteridol) tsim los ntawm Bracco, Omniscan (gadodiamide) tsim los ntawm GE Healthcare, thiab OptiMARK (gadoversetamide) tsim los ntawm Mallinckrod.

Gadolinium raws cov neeg sawv cev tuaj yeem ua rau muaj tshuaj lom lom hu ua nephrogenic systemic fibrosis (NSF) hauv cov neeg mob uas muaj teeb meem mob raum loj.

Piv rau lwm cov gadolinium-based MRI tus neeg sawv cev sib piv, Gadopentetate dimeglumine (Gd-DTPA2-) chelates tso cai ncua Gadolinium-txhim kho Sib Nqus Resonance ntawm Pob txha mos (dGEMRIC). Qhov tshwj xeeb tus yam ntxwv ntawm txoj kab ke no tso cai rau cov kws tshawb fawb ntsuas kev sib tw ntsuas lub sijhawm so kom txaus raws li lawv cuam tshuam nrog kev tsom mus rau cov protein proteoglycan sib sau ua ke thiab them glycosaminoglycan sab saw hauv pob txha mos pob txha.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: gadopentetate dimeglumine cas 86050-77-3, cov chaw tsim khoom, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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