Fostamatinib CAS 901119-35-5

Product Description:

Khoom npe: Fostamatinib CAS 901119-35-5

 

Synonyms:

FostaMatinib Disodium;

{{0}[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,{{ 8}}dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,{13}}b]-1,4-oxazin-3 (4H) - ib.

 

Chemical & Physical Properties

Cov tsos mob: Dawb rau Off-White khoom

Kev Ntsuas: NLT98%

Cov mis mos molecular: C23H26FN6O9P

Molecular Luj: 580.46

Melting point: 214 degree ~ 217 degree

Kub taw tes: 814.2 ± 75. 0 degree (Predicted)

Qhov ceev: 1.496

Cia kub: -20 degree, Hygroscopic

Solubility: DMSO (me ntsis), Methanol (me ntsis)

Pka: 1.7 0 ± 0.10 (Predicted)

Vapor Pressure: {{0}}.0 ± 3.1 mmHg ntawm 25 degree

Index ntawm Refraction: 1.629

 

Siv:

Hauv vitro: R788 yog methylene phosphate prodrug ntawm R406, uas tuaj yeem hloov pauv mus rau R406 hauv vivo: R406 (hauv vitro active daim ntawv ntawm R788) xaiv inhibits Syk-dependent signaling nrog EC50 qhov tseem ceeb xws li 33 nM mus rau 171 nM, muaj zog dua li Syk-kev ywj pheej txoj hauv kev sib txawv. R406 inhibits cellular proliferation ntawm ntau yam diffuse loj B-cell lymphoma (DLBCL) cell kab nrog EC50 qhov tseem ceeb xws li 0.8 μM txog 8.1 μM. Kev kho R406 txo qis basal phosphorylation ntawm BLNK, Akt, glycogen synthase kinase-3 (GSK-3), forkhead box O (FOXO) thiab ERK tsis yog hauv cov hlwb uas muaj siab (TCL{20}}) tab sis kuj nyob rau hauv cov hlwb uas tsis tshua muaj phosphorylated Syk (TCL1-551). Tsis tas li ntawd, R406 tag nrho inhibits anti-IgM induced Bcr teeb liab hauv TCL1 leukemias. Txawm hais tias muaj qib siab dua ntawm kev ua haujlwm Syk hauv TCL1 leukemias, R406 tsis yog xaiv cytotoxic rau cov hlwb leukemic.

Hauv vivo: R788 zoo inhibits BCR signaling hauv vivo, ua rau txo qis kev loj hlob thiab ciaj sia ntawm cov kab mob B hlwb thiab ua rau muaj sia nyob ntev ntawm cov tsiaj kho.

 

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

 

Cov khoom raws li patent yog muab rau R & D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: fosamatinib cas 901119-35-5, manufacturers, lwm tus neeg, Hoobkas, yuav, Tshuag

• Tug: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile CAS 1240948-72-4
• Tom ntej: N'-(4-Amino-2-cyanophenyl)-N, N-dimethylformamidine CAS 194423-17-1