Escitalopram Oxalate CAS 219861-08-2

Khoom Piav Qhia:

Khoom Lub Npe: Escitalopram oxalate CAS TSIS TAU: 219861-08-2

Lub ntsiab lus:

(S) -Citalopram Oxalate;

1- [3- (dimethylamino) propyl] -1- (4-fluorophenyl) -1,3-dihydro-5-isobenzofuran-carbonitrile oxalate;

S-(+)-1-3- (dimethyl-amino) propyl-1- (p-fluorophenyl) -5-phthalancarbonitrileoxalate;

Tshuaj& Lub Cev Muaj Zog:

Tsos: Dawb dawb

Kev Ntsuas: ≥99.00%

Kub Point: 428.3 ℃ ntawm 760 mmHg

Melting Point: 152-153 ℃

Flash Point: 212.8 ℃

Cov Ntaub Ntawv Kev Nyab Xeeb:

Cov Lus Hais Txog Kev Nyab Xeeb: S26; S36

Cov Lus Qhia Risk: R36/37/38

Tus lej phom sij: Xi

WGK Lub Tebchaws Yelemees: 3

RTECS: NP6333500

HS Code: 29322090

Ib qho inhibitor ntawm serotonin (5-HT) kev nqus. Antidepressant. Escitalopram tau pib ua Cipralex? hauv Switzerland, Sweden thiab UK rau kev kho mob ntawm kev nyuaj siab thiab tsis meej pem. Nws yog S-enantiomer version ntawm kev xaiv serotonin reuptake inhibitor (SSRI) citalopram tau pom zoo xyoo 1989. Nws tuaj yeem tau txais los ntawm 5cyanophthalide los ntawm kev cuam tshuam nrog 4-fluorophenyl magnesium bromide thiab 3- (dimethylamino) propyl magnesium chloride. Qhov tshwm sim racemic diol tuaj yeem daws tau los ntawm ntau txoj hauv kev xws li crystallization nrog chiral acid. Thaum kawg, ob kauj ruam kev caij tsheb kauj vab ua rau muaj escitalopram. Escitalopram tau siv ob zaug zoo dua li cov neeg sib tw thiab ntau dua 100 npaug ntau dua li R-enantiomer hauv kev txwv 5HT rov ua dua hauv vivo hauv nas lub hlwb synaptosomes. Ntxiv mus, nws nthuav tawm kev xaiv ntau dua rau tib neeg cov tshuaj serotonin thauj tus txheeb ze rau noradrenaline lossis dopamine cov neeg thauj khoom ntau dua li lwm qhov tam sim no muaj SSRl's. Hauv nas yuam kev sim ua luam dej, lub sijhawm ua kom tsis muaj zog (uas qhia txog kev ua haujlwm tiv thaiv kev nyuaj siab) rau escitalopram piv rau citalopram thiab ntau dua (R) -citalopram. Kev soj ntsuam kuaj mob hauv cov neeg mob uas muaj teeb meem tsis txaus ntseeg lossis kev nyuaj siab tau qhia tias escitalopram muaj kev kho mob muaj feem cuam tshuam thiab muaj txiaj ntsig zoo. Ib qho ntxiv, nws muaj qhov pib ua haujlwm tiv thaiv kev nyuaj siab sai dua citalopram. Escitalopram muaj cov tshuaj pharmacokinetics linear, nrog rau ib nrab-lub neej ntev (27-32 h). Nws tau hloov pauv ntau hauv lub siab ntawm cytochromes P450 rau S (+)-desmethyl thiab S (+)-didesmethyl citalopram. Txawm li cas los xij, nws tau pom tias ua rau lub cev tsis muaj zog lossis tsis muaj peev xwm txwv tsis pub siv CYP450 cov tshuaj ua kom muaj cov enzymes hauv vitro. Escitalopram tau zam zoo nrog xeev siab yog qhov tshwm sim tshwm sim feem ntau.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: escitalopram oxalate cas 219861-08-2, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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