DACARBAZINE CAS 4342-03-4

Khoom Piav Qhia:

Khoom Lub Npe: DACARBAZINE CAS TSIS TAU: 4342-03-4

Lub ntsiab lus:

5- (3,3-dimethyl-1-triazenyl) -1H-imidazole-4-carboxamide;

1H-Imidazole-4-carboxamide, 5- (3,3-dimethyl-1-triazenyl)-;

5- (3,3-Dimethyl-1-triazenyl) imidazole-4-carboxamide, DTIC;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Cov xim daj lossis xim liab

Kev Ntsuas: ≥99.0%

Ceev: 1.48 g/cm3

Kub Point: 456.3 ℃ ntawm 760 mmHg

Melting Point: 199-205 ℃

Flash Point: 229.7 ℃

Refractive Index: 1.678

Kev Ruaj Ntseg: Ruaj khov ntawm chav sov hauv cov thawv kaw hauv qhov qub cia thiab tuav cov xwm txheej.

Cia Li Cas: 2-8 ℃

Dej Solubility: Dej me ntsis hauv dej, DMSO thiab ethanol /n

Cov Ntaub Ntawv Kev Nyab Xeeb:

RTECS: NI3950000

Cov Lus Hais Txog Kev Nyab Xeeb: S53-S36/37/39-S45

HS Code: 2933290090

WGK Lub Tebchaws Yelemees: 3

Cov Ntsiab Lus Risk: R45; R46; R20/21/22; R36/37/38

Cov lej phom sij: T, Xi, Xn

Kev Tshaj Tawm Kev Nyab Xeeb: H302, H312, H332; H315; H319; H335; H340; H350

Cov lus ceeb toom ceeb toom: P201; P261; P280; P305, P351, P338; P308 thiab P313

Lo Lus Teeb Meem: Txaus Ntshai

Cov cim: GHS07, GHS08

Dacarbazine (hom tshuaj npe DTIC, DTIC-Dome; tseem hu ua DIC lossis imidazole carboxamide) yog cov tshuaj siv tshuaj tiv thaiv kab mob antineoplastic siv hauv kev kho mob qog noj ntshav ntau yam, ntawm lawv mob qog noj ntshav, Hodgkin' s lymphoma, sarcoma, thiab islet cell carcinoma ntawm lub txiav.

Dacarbazine yog tus tswv cuab ntawm chav kawm ntawm cov neeg ua haujlwm alkylating, uas rhuav tshem cov qog nqaij hlav cancer los ntawm kev ntxiv ib pawg alkyl (CnH2n+1) rau nws cov DNA.

Dacarbazine feem ntau yog tswj hwm los ntawm kev txhaj tshuaj (IV) raws li kev saib xyuas tam sim ntawm kws kho mob lossis kws saib xyuas neeg mob. Dacarbazine yog bioactivated hauv siab los ntawm demethylation rau" MTIC" thiab tom qab ntawd mus rau diazomethane, uas yog tus neeg sawv cev alkylating.

Nws yog nyob rau hauv WHO Tus Qauv Cov Npe ntawm Cov Tshuaj Tseem Ceeb, cov tshuaj tseem ceeb tshaj plaws uas xav tau hauv cov txheej txheem kev noj qab haus huv. Nws yog tus neeg sawv cev antineoplastic. Nws tau siv hauv tsev kho mob rau kev kho mob qog noj ntshav melanoma nrog ua tau zoo li ntawm 20-30% tus neeg mob. Ua ke nrog vincristine thiab BCNU tuaj yeem txhim kho kev ua tau zoo ntxiv. Ib qho ntxiv, nws kuj muaj qee qhov ua tau zoo hauv kev kho mob ntsws squamous cell carcinoma, sarcoma, leiomyosarcoma thiab fibrosarcoma tab sis nrog kev ua haujlwm tsis zoo hauv kev kho mob qog noj ntshav hnyuv.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: dacarbazine cas 4342-03-4, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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