Clofarabine CAS 123318-82-1

Khoom Piav Qhia:

Khoom Lub Npe: Clofarabine CAS TSIS TAU: 123318-82-1

Lub ntsiab lus:

(2R, 3R, 4S, 5R) -5- (6-amino-2-chloropurin-9-yl) -4-fluoro-2- (hydroxymethyl) oxolan-3-ol;

2-Chloro-9- (2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine;

2-chloro-2' -arabino-fluoro-2' -deoxyadenosine;

Tshuaj& Lub Cev Muaj Zog:

Tsos: Dawb dawb

Kev Ntsuas: ≥99.00%

Ceev: 2.12 g/cm3

Kub Point: 550 ℃ ntawm 760 mmHg

Melting Point: 228-231 ℃

Flash Point: 286.4 ℃

Refractive Index: 1.843

Vapor Siab: 3.19E-15mmHg ntawm 25 ℃

Cov Ntaub Ntawv Kev Nyab Xeeb:

RTECS: DP5550000

Chav Kawm Muaj Kev Nyab Xeeb: 8

Cov Lus Hais Txog Kev Nyab Xeeb: S26; S36; S45; S36

WGK Lub Tebchaws Yelemees: 3

Cov Pab Pawg: III

RIDADR: UN 2735 8/PG 3

Cov Lus Qhia Risk: R36/37/38; R20/21/22

Cov lej phom sij: Xi; C

Cov lus ceeb toom ceeb toom: P264; P301 thiab P310

Lo Lus Teeb Meem: Txaus Ntshai

Cim: GHS06

Kev Tshaj Tawm Kev Nyab Xeeb: H300

Thib ob tiam purine nucleoside analog; antimetabolite uas inhibits DNA synthesis thiab tiv thaiv deamination los ntawm adenosine deaminase. Antineoplastic.

Clofarabine (Clolar; Clofarex) inhibits enzymatic kev ua ub no ntawm ribonucleotide reductase (IC50=65 nM) thiab DNA polymerase.IC50 Tus nqi: 65 nMTarget: hauv vitro: Clofarabine yog tiam thib ob purine nucleoside analog nrog cov tshuaj antineoplastic. Nws yog phosphorylated intracellularly, uas cuam tshuam kev ua haujlwm enzymatic ntawm ribonucleotide reductase (IC50=65 nM) thiab DNA polymerase, ua rau cuam tshuam kev kho DNA thiab ua ke ntawm DNA thiab RNA. Qhov nucleoside analog no tseem cuam tshuam rau mitochondrial muaj nuj nqi thiab ua kom lub cev ruaj khov, ua rau tso tawm ntawm pre-apoptotic yam, suav nrog cytochrome C thiab apoptotic-inducing factor, uas ua rau apoptosis.in vivo: Clofarabine siv rau kev kho mob rov qab los yog tsis tuaj yeem ua rau mob qog ntshav qog ntshav (ALL) ) hauv cov menyuam yaus, tom qab tsawg kawg ob hom kev kho mob tau ua tsis tiav.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: clofarabine cas 123318-82-1, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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