Clevidipine Butyrate CAS 167221-71-8

Khoom Piav Qhia:

Khoom Lub Npe: Clevidipine butyrate CAS TSIS TAU: 167221-71-8

Lub ntsiab lus:

5-O- (butanoyloxymethyl) 3-O-methyl4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;

Cleviprex;

Clevidipine butyrate;

Tshuaj& Lub Cev Muaj Zog:

Tsos: Hmoov

Kev Ntsuas: ≥99.00%

Ceev: 1.289g/cm3

Kub Point: 539.7 ℃ ntawm 760mmHg

Flash Point: 280.2 ℃

Melting Point: 128-130 ℃

Cia Temp.: Tub yees

Vapor Siab: 0.0 ± 1.4 mmHg ntawm 25 ℃

Index ntawm Refraction: 1.543

Cov Ntaub Ntawv Kev Nyab Xeeb:

Cov Lus Hais Txog Kev Nyab Xeeb: S24/25

Tus lej HS: 29339900

Calcium channel blocker, siv los ua tshuaj tiv thaiv qhov ncauj.

Clevidipine yog qhov ua luv luv dihydropyridine calcium channel antagonist (IC50 = 7.1 nM, V (H) = -40 mV) hauv kev txhim kho rau kev kho mob ntshav qab zib perioperative.IC50 Tus nqi: 7.1 nM ntawm V (H) = -40 mV [1] Lub hom phiaj: calcium channelin vitro: Ob qho tib si clevidipine thiab nitroglycerin thim rov qab U46619-induced contraction (clevidipine (50 % siv tau zoo [EC50] = 3.88 +/-0.84 x 10 (-6) mol/L, nitroglycerin EC50 = 4.84 +/ -2.76 x 10 (-8) mol/L) [2]. Kev txo qis hauv qhov kub tau nce ib nrab-lub neej ntawm clevidipine hauv cov ntshav, thaum cov ntshav dilution tsis cuam tshuam rau hauv vitro ib nrab-lub neej ntawm clevidipine. cuam ​​tshuam rau cov tshuaj hydrolysis ntawm clevidipine hauv RBC raug tshem tawm nrog cov ntsev [3] .in vivo: Clevidipine yog cov tshuaj tshem tawm siab nrog rau qhov faib me me, uas ua rau luv luv ib nrab ntawm lub neej hauv txhua hom kawm. -lub neej ntawm tus kheej tus nqi (Bayesian kwv yees) yog 12, 20, thiab 22 s hauv luav, nas, thiab d og, sib [4]. Qhov txiaj ntsig siab tshaj plaws ntawm kev tshem tawm thiab qhov ntim me me ntawm kev faib tawm ua rau luv ib nrab-lub neej ntawm clevidipine, 2.2 thiab 16.8 min, feem. Ntshav siab thiab koob tshuaj ua rau ib nrab qhov ua tau zoo tshaj plaws (piv txwv li EC50 thiab ED50) tau kwv yees li 25 nM thiab 1.5 microg/kg/min, feem [5] .Kev tshuaj ntsuam xyuas: CARVE: Clevidipine rau Vasoreactivity Kev Ntsuam Xyuas ntawm Pulmonary Arterial Bed. Theem 4

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Cim npe nrov: clevidipine butyrate cas 167221-71-8, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

• Tug: Manidipine CAS 89226-50-6
• Tom ntej: Pranidipine CAS 99522-79-9