Caronic Anhydride CAS TSIS TAU

Product Description:

Khoom npe: Caronic anhydride CAS 67911-21-1

 

Synonyms:

6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione;

Meldrum's acid;

3, 3-Dimethyl-1, 2-cyclopropanedicarboxylic Anhydride

 

Chemical & Physical Properties

Cov tsos mob: Dawb mus rau Yuav luag dawb hmoov rau siv lead ua

Qhov ceev: 1.3 ± {2}}.1 g / cm3

Boiling Point: 246.3 ± 9. 0ºC ntawm 760 mmHg

Melting Point: 52-55ºC

Flash Point: 112.7 ± 15.9 degree

Qhov Loj: 140.047348

PSA: 43.37000

LogP: -0.42

Vapor Pressure: {{0}} 0± 0.5 mmHg ntawm 25 degree

Index ntawm Refraction: 1.499

 

Cov ntaub ntawv kev nyab xeeb

HazardClass: IRRITANT

HS Code: 2914199090

 

Kev siv:

Karonic anhydride, tseem hu ua 6,6-dimethyl-3-oxabicyclo [3.1.0] hexane-2,4-dione, yog cov tshuaj nruab nrab, feem ntau yog siv los ua cov synthesis ntawm Boceprevir, qhov ncauj chemobook protease inhibitor ntawm kab mob siab C. Boceprevir yog qhov ncauj kab mob siab C protease inhibitor tsim los ntawm Schering-Plough yam tsis muaj kev hloov kho.

Caronic anhydride tuaj yeem siv los ua cov tshuaj nruab nrab, feem ntau yog rau kev sib txuas ntawm qhov ncauj kab mob siab C protease inhibitor Boceprevir.

Kauj Ruam 1: Ntxiv 200g ntawm ethyl acetate rau 500mL hwj, tom qab ntawd ntxiv 94.8g (0.4mol) ntawm ethyl dichloroferrate, txias rau -5 degree , thiab pib cov tshuaj tiv thaiv nrog tus nqi ntws ntawm 2L / min los ntawm kev qhia ozone nrog lub ntim concentration ntawm 3% (qhov seem yog huab cua, tib yam hauv qab no). Thaum cov tshuaj tiv thaiv, txheeb xyuas cov ntaub ntawv raw los ntawm cov roj chromatography. Tom qab hloov pauv tus nqi ntawm ethyl dichloroferrate tshaj 99%, nres qhov kev txhaj tshuaj ozone. Tom qab cov tshuaj tiv thaiv tiav, dej ntxiv rau ntxuav thiab txheej txheej roj, ntxuav ob zaug, nrog 100ml dej txhua zaus. Tom qab ntxuav, cov roj txheej yog evaporated thiab concentrated kom tshem tawm cov kuab tshuaj. Tom qab ntawd, 70g ntawm 30% kua alkali yog ntxiv rau cov khoom siv tshuaj tiv thaiv ntxiv rau saponification cov tshuaj tiv thaiv. Lub sijhawm no, pH ntau dua 12, thiab cov tshuaj tiv thaiv tau khaws cia ntawm qhov kub ntawm 50-60 degree rau 2 teev. Tom qab ntawd, 30% hydrochloric acid yog ntxiv rau cov tshuaj tiv thaiv rau cov tshuaj tiv thaiv acidification kom txog thaum tus nqi pH nce mus txog 1-2, thiab cov tshuaj tiv thaiv kub yog tswj ntawm 40-50 degree, rwb thaiv tsev cov tshuaj tiv thaiv rau 1 teev. Tom qab poob rau hauv chav tsev kub, muab rho tawm nrog Chemicalbook methyl tert butyl ether, 100ml txhua zaus, peb zaug, thiab sib koom ua ke cov organic txheej txheej. Ua kom cov kuab tshuaj los ntawm lub tshuab nqus tsev vacuum ntawm 50mmHg kom tau 57.3g ntawm 3,3-dimethyl-1,2-cyclopropane dicarboxylic acid, nrog rau GC normalized cov ntsiab lus ntawm 98.2% thiab molar yield ntawm txog 84%. Kauj Ruam 2: Ntxiv 50g ntawm 3,3-dimethyl-1,2-cyclopropane dicarboxylic acid rau hauv cov tshuaj tiv thaiv lub raj mis, tom qab ntawd ntxiv 30g ntawm acetic anhydride thiab 0.5g ntawm sodium acetate, thiab tom qab ntawd kub. mus rau 170 degree C rau cov tshuaj tiv thaiv. Thaum cov txheej txheem cua sov, qee cov acetic acid thiab acetic anhydride generated thaum lub sij hawm cov tshuaj tiv thaiv raug tshem tawm. Tom qab cov tshuaj tiv thaiv ua tiav, txias mus rau 50-70 degree C thiab ua qhov tsis zoo siab desorption kom tau 37.6g ntawm cov khoom. Tom qab ntawd, ntxiv 30ml ntawm toluene thiab 90ml ntawm roj av ether rau recrystallization, 33.2g ntawm 6, 6-dimethyl-3-oxabicyclo [3.1.0] hexane-2, 4-dione yog tau, nrog cov ntsiab lus normalized ntawm 99.6% thiab tawm los ntawm 74.8%.

 

 

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

 

 

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Cim npe nrov: caronic anhydride cas 67911-21-1, manufacturers, lwm tus neeg, Hoobkas, yuav, Tshuag

• Tug: 6,6-Dimethyl-3-azabicyclo[3.1.
• Tom ntej: Flumequine CAS 42835-25-6