Benazepril Hydrochloride CAS 86541-74-4

Khoom Piav Qhia:

Khoom Lub Npe: Benazepril hydrochloride CAS TSIS TAU: 86541-74-4

Lub ntsiab lus:

2-[(3S) -3-[[(2S) -1-ethoxy-1-oxo-4-phenylbutan-2-yl] amino] -2-oxo-4,5-dihydro-3H-1-benzazepin- 1-yl] acetic acid, hydrochloride;

1h-1-benzazepine-1-aceticacid, 2,3,4,5-tetrahydro-3-((1- (ethoxycarbonyl) -3-phe;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Dawb crystalline khoom

Kev Ntsuas: ≥99.00%

Kub Point: 691.2 ℃ ntawm 760 mmHg

Melting Point: 188-190 ℃

Flash Point: 371.8 ℃

Kev Cia Cia: Desiccate ntawm +4 ℃

Cov Ntaub Ntawv Kev Nyab Xeeb:

RTECS: CX7065000

Cov Lus Hais Txog Kev Nyab Xeeb: S22-S24/25

HS Code: 2933990090

WGK Lub Tebchaws Yelemees: 2

Benazepril hydrochloride, angiotensin hloov pauv enzyme inhibitor, uas yog tshuaj siv los kho ntshav siab.Qhov chaw: angiotensin hloov pauv enzyme (ACE) Benazepril hydrochloride yog tshuaj siv los kho ntshav siab (ntshav siab), mob plawv tsis ua haujlwm, thiab mob raum ntev tsis ua hauj lwm. Thaum cleavage ntawm nws pawg ester los ntawm daim siab, benazepril hydrochloride tau hloov pauv mus rau nws daim ntawv nquag benazeprilat, tsis-sulfhydryl angiotensin-hloov pauv enzyme (ACE) inhibitor [1] .Txhua tus tsiaj tau raug faib ua plaub pawg: sham STNx pab pawg (tswj) , STNx pab pawg, thaum sawv ntxov benazepril hydrochloride pawg (MB) thiab yav tsaus ntuj benazepril hydrochloride pawg (EB). Benazepril hydrochloride tau muab intragastrically muab tshuaj ntawm 10 mg/kg/hnub thaum 07:00 thiab 19:00 hauv MB pab pawg thiab EB pab pawg feem rau 12 lub lis piam. Txhua tus tsiaj tau sib txuas ua ke rau qhov pom kev: lub voj voog tsaus ntuj ntawm 12:12 rau 12 lub lis piam. Ntshav siab ntshav siab (SBP), 24-h tso zis protein ntau thiab lub raum ua haujlwm tau ntsuas ntawm 11 lub lis piam. Kev kuaj ntshav thiab lub raum tau sau txhua txhua 4 teev nyob rau ib hnub txhawm rau txheeb xyuas cov qauv kev ua haujlwm ntawm renin (RA), angiotensin II (AngII) thiab aldosterone (Ald) los ntawm radioimmunoassay (RIA) thiab mRNA qhia txog keeb kwm ntawm lub moos (bmal1, dbp thiab per2) los ntawm PCR lub sijhawm tiag tiag ntawm 12 lub lis piam. Peb cov txiaj ntsig tau pom tias tsis muaj qhov sib txawv tseem ceeb tau sau tseg hauv SBP, 24-h cov zis protein tso tawm thiab lub raum ua haujlwm ntawm pawg MB thiab EB. Tsis muaj qhov sib txawv tseem ceeb hauv nruab nrab Ald thiab RA cov ntsiab lus ntawm ib hnub ntawm MB pawg thiab EB pab pawg. Qhov siab tshaj plaws ntawm bmal1 mRNA tau ncua sijhawm los ntawm 4 txog 8 teev, thiab kev hloov pauv ntawm ib hnub ntawm per2 thiab dbp mRNA tsawg zuj zus hauv MB thiab EB pawg piv nrog kev tswj hwm thiab STNx pawg. Nws tau xaus thaum qhov zoo sib xws SBP txo qis, RAAS inhibition thiab moos gene profile tau ua tiav nrog qib pom zoo ntawm benazepril hydrochloride, thaum sawv ntxov piv rau yav tsaus ntuj noj benazepril hydrochloride muaj qhov cuam tshuam zoo ib yam renoprotection [2] .Clinical indications: Congestive heart failure; Kab mob hauv lub raum kawg; HypertensionFDA Pom Zoo Hnub: Toxicity: mob taub hau; hnoos; Kev ua xua; angioedema; hyperkalemia

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Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: benazepril hydrochloride cas 86541-74-4, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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