Atazanavir Sulfate CAS 229975-97-7

Khoom Piav Qhia:

Khoom Lub Npe: Atazanavir sulfate CAS TSIS TAU: 229975-97-7

Lub ntsiab lus:

N-[(2S) -1- [2-[(2S, 3S] -2-hydroxy-3-[[(2S) -2- (methoxycarbonylamino] -3,3-dimethyl-1-oxobutyl] amino]) 4-phenylbutyl] -2-[(4-phenylphenyl) methyl] hydrazinyl] -3,3-dimethyl-1-oxobutan-2-yl] carbamic acid methyl;

1- (4-Biphenylyl) -4 (S) -hydroxy-5 (S) -2,5-bis {[N- (methoxycarbonyl-)-L-tert-leucinyl] amino} -6-phenyl-2-azahexane ;

BMS-232632 sulfate;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Tawm-Dawb Khoom

Kev Ntsuas: ≥99.0%

Ceev: 1.164g/cm3

Kub Point: 995.5 ℃ ntawm 760 mmHg

Flash Point: 555.8 ℃

Vapor Siab: 0mmHg ntawm 25 ℃

Cov Ntaub Ntawv Kev Nyab Xeeb:

Cov Lus Hais Txog Kev Nyab Xeeb: S24/25

HS Code: 29333990

Atazanavir yog qhov tshiab azapeptide HIV protease inhibitor (PI). Tshuaj tua kab mob. Atazanavir sulfate yog sulfate ntsev daim ntawv ntawm atazanavir uas yog muaj zog heev HIV-1 protease inhibitor.Target: HIV-1 protease inhibitorAtazanavir sulfate yog sulfate ntsev daim ntawv ntawm atazanavir uas yog qhov muaj zog heev HIV-1 protease inhibitor. Nws muaj cov tshuaj pharmacokinetic uas txhawb nqa ib hnub ib zaug thiab tau qhia txog qhov tshwj xeeb tiv thaiv kab mob thiab muaj zog tiv thaiv kab mob zoo dua piv nrog lwm cov tshuaj tiv thaiv kab mob hauv vitro. Hauv cov kab mob HIV, atazanavir (400 mg ib hnub ib hnub) ua rau muaj kev txhim kho sai thiab ruaj khov hauv kev kis kab mob thiab CD4 suav hauv ob qho tshuaj tiv thaiv kab mob vwm-zoo li yav dhau los kho cov neeg mob thaum siv ua ke nrog ob lub nucleoside reverse transcriptase inhibitor (NRTI) kho [1] ]. Tom qab txhaj tshuaj (iv), qhov ncauj (po) thiab intraportal (ip) kev tswj hwm ntawm ATV ntawm qhov ntau npaum li 7 mg/kg, AUCs hauv HL nas yog 12.41, 5.24 thiab 8.89 microg/mLh, feem ntau, thiab siab dua cov uas tswj cov nas (4.09, 1.70 thiab 3.38 microg/mLh). Txawm hais tias qhov txo qis ntawm kev faib khoom faib (Vd (ss)), lub davhlau ya nyob twg ib nrab ntawm lub neej (t (1/2)) hauv HL tended kom luv dua li kev tswj hwm, thiab lub siab faib ATV hauv HL nas yog 4.8-npaug nce. Cov txiaj ntsig no tau qhia tias kev nqus ATV rau hauv lub siab tuaj yeem tiv thaiv qhov txo qis ntawm Vd (ss). Ntawm qhov tod tes, tsis muaj qhov sib txawv tseem ceeb hauv kev muaj sia nyob, thiab kev thauj cov kua lymphatic mus rau AUC pom tsis muaj kev hloov pauv ntawm tus lej. Hauv qhov xaus, txawm hais tias tus nqi khi cov protein thiab AUC tau nce ntau, cov tshuaj pharmacokinetics ntawm ATV tuaj yeem zam hauv HL [2]. Cov lus qhia kho mob: HIV-1 kev kis tus mob Toxicity: torsades de pointes.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: atazanavir sulfate cas 229975-97-7, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

• Tug: Bisibutiamine CAS 3286-46-2
• Tom ntej: Bicalutamide CAS 90357-06-5