Aprocitentan CAS 1103522-45-7

Product Description:

Khoom npe: Aprocitentan CAS 1103522-45-7

 

Synonyms:

N-Despropyl-macitentan;

5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine;

 

Chemical & Physical Properties:

Cov tsos mob: dawb mus rau cov hmoov dawb dawb

Assay: Ntau dua lossis sib npaug rau 99.0%

Melting Point: 139-141 degree

Qhov ceev: 1.841g / cm3

Solubility: soluble hauv chloroform (me ntsis rhuab), methanol (me ntsis rhuab)

 

Siv

N-Despropyl-macitentan, yog ib qho active metabolite uas yog ib feem ntawm tsev neeg ntawm endothelin receptor antagonist uas tso cai rau kev kho mob ntawm pulmonary arterial hypertension (PAH).

 

ACT-132577 yog ib tug tswv cuab ntawm chav kawm ntawm sulfamides nyob rau hauv uas ib qho ntawm cov amino pawg ntawm sulfonamide yog hloov los ntawm ib tug 5-(4-bromophenyl)-6-{{{4} [(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4- pawg yl. Ib qho active metabolite ntawm macitentan (tau los ntawm oxidative depropylation), ib tug menyuam ntsuag tshuaj siv rau kev kho mob ntawm pulmonary arterial hypertension. Nws muaj lub luag haujlwm ua tus neeg saib xyuas ntshav siab, endothelin receptor antagonist, tshuaj metabolite thiab xenobiotic metabolite. Nws yog ib qho aromatic ether, ib qho organobromine compound, ib tug tswv cuab ntawm pyrimidines thiab ib tug tswv cuab ntawm sulfamides. Nws muaj feem cuam tshuam nrog ethylene glycol.

 

 

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

 

Cov khoom raws li patent yog muab rau R & D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: aprocitentan cas 1103522-45-7, manufacturers, lwm tus neeg, Hoobkas, yuav, Tshuag

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