Ansamitocin P-0 CAS 57103-68-1

Product Description:

Khoom npe: Ansamitocin P-0 CAS NO: 57103-68-1

Synonyms:

O3-de-(N-acetyl-N-methyl-L-alanyl)-maytansine;

(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84,12c-dihydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-1,3oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione;

Maytansinol (7);

Chemical Physical Properties:

Cov tsos mob: hmoov

Assay: Ntau dua lossis sib npaug rau 99.0 feem pua

Qhov ceev: 1.34g / cm3

Boiling Point: 835.8 degree ntawm 760mmHg

Flash Point: 459.3 degree

Refractive Index: 1.607

Vapour Pressure: {{0}}.0±3.2 mmHg at 25 degree

Maytansinol yog siv nyob rau hauv kev npaj ntawm qhov chaw - tshwj xeeb trastuzumab maytansinoid antibody - tshuaj conjugates nrog txhim kho kev ua haujlwm. Maytansinol inhibits microtubule sib dhos thiab induces microtubule disassembly hauv vitro.Tim: Microtubule/Tubulinin vitro: Maytansinol cuam tshuam lub mitotic spindle thiab tiv thaiv mitotic tawm hauv Drosophila. Maytansinol txo qhov kev loj hlob thiab/los yog ciaj sia ntawm HCT116 hlwb nyob rau hauv ib koob-raws li txoj kev thiab hais tias cov nyhuv yog hnyav dua rau p53 ntxiv / ntxiv rau p53-/- hlwb ntawm ob qho tib si koob tshuaj tsawg thiab siab. Maytansinol inhibits kev loj hlob ntawm HCT116 tib neeg cov kab mob qog noj ntshav. Maytansinol induces apoptosis nyob rau hauv lub tswv yim discs ntawm qus{12}} hom larvae tab sis tsis p53 mutant larvae. Qhov no sib piv qhov kev tshawb pom hauv tib neeg HCT116 hlwb, uas Maytansinol tau zoo dua thaum p53 nyob, tsawg kawg ntawm qee qhov koob tshuaj. Maytansinol induces apoptosis nyob rau hauv lub tswv yim discs ntawm qus-hom larvae tab sis tsis p53 mutant larvae ntawm 24 teev tom qab raug tshuaj.

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Cim npe nrov: anamitocin p-0 cas 57103-68-1, tuam ntxhab, lwm tus muag khoom, Hoobkas, yuav, hauv Tshuag

• Tug: Ansamitocin P-3 CAS 66584-72-3
• Tom ntej: MonoMethyl Auristatin E (MMAE) CAS 474645-27-7