AFP-168 CAS 209860-87-7

Khoom Piav Qhia:

Khoom Lub Npe: AFP-168 CAS TSIS TAU: 209860-87-7

Lub ntsiab lus:

propan-2-yl (Z) -7-[(1R, 2R, 3R, 5S) -2-[(E) -3,3-difluoro-4-phenoxybut-1-enyl] -3,5-dihydroxycyclopentyl] hept-5-enoate;

Taflotan;

Tafluprost;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: daj daj tuab cov roj

Kev Ntsuas: ≥99.00%

Ceev: 1.186 g/cm3

Kub Point: 552.9 ℃ ntawm 760mmHg

Flash Point: 288.2 ℃

Refractive Index: 1.548

Vapor Siab: 4.62E-13mmHg ntawm 25 ℃

Tafluprost yog cov tshuaj prostanoid tshiab siv hauv kev kho mob glaucoma thiab yog thawj cov tshuaj prostanoid uas tau tso tawm hauv cov tshuaj tsis pub dawb. Glaucoma yog qhov thib ob tsuas yog cataracts yog qhov ua rau pom qhov muag tsis pom. Txog xyoo 2010, kwv yees tias kwv yees li 60 lab tus tib neeg thoob ntiaj teb yuav raug kev txom nyem los ntawm glaucoma, yog li kev kho mob zoo yuav tsum tau txais kev lag luam loj. PG analogs tau siv dav rau txo qis IOP los ntawm kev nce uveoscleral ntws los ntawm agonism ntawm prostanoid FP receptor, thiab tam sim no kev lag luam suav nrog latanoprost, unoprostone isopropyl ester, bimatoprost, thiab travoprost. Piv rau carboxylic acid ntawm latanaprost (Ki=4.7 nM), carboxylic acid ntawm tafluprost tau nthuav tawm 10-npaug ntau dua kev sib raug zoo rau prostanoid FP receptor (Ki=0.4 nM). Kev sib xyaw ntawm tafluprost pib nrog Wittig hws ntawm kev tiv thaiv bicyclic lactone carbaldehyde nrog dimethyl phosphonate ketone derivative.

Piv rau carboxylic acid ntawm latanaprost (Ki 4.7 nM), carboxylic acid ntawm tafluprost tau nthuav tawm 10-quav ntau dua kev nyiam rau prostanoid FP receptor (Ki 0.4 nM). Kev sib xyaw ntawm tafluprost pib nrog Wittig hws ntawm kev tiv thaiv bicyclic lactone carbaldehyde nrog dimethyl phosphonate ketone derivative. Cov kab ntawv hauv qab yog tom qab ua tiav los ntawm kev ua kom fluorination ntawm ketone nrog morpholino-sulfur trifluoride. Hydrolysis ntawm benzoate ester tiv thaiv pab pawg pab pawg hydroxy, thiab txo cov lactone ua tiav nrog aluminium hydride los tsim cov lactol. Kev sib xyaw ua ke ntawm qhov nruab nrab nrog phosphonium ntsev ntawm cov kua qaub sab ua rau muaj cov kua qaub dawb, lossis cov khoom xyaw nquag, uas tom qab esterified nrog 2-iodopropane thaum muaj DBU.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: afp-168 cas 209860-87-7, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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