4-Nitrobenzyl Hydrogen Malonate CAS 77359-11-6

Product Description:

Khoom npe: 4-Nitrobenzyl hydrogen malonate CAS 77359-11-6

 

Synonyms:

Malonic acid mono{0}}nitrobenzyl ester;

Malonicacidmononitrobenzylester;

 

Chemical & Physical Properties

Tsos: Dawb rau Yuav luag dawb hmoov

Kev Ntsuas: 99% +

Melting point: 109 degree

Kub taw tes:: 455.8 ± 3 0.0 degree

Qhov ceev: 1.447 ± {2}}.06g / cm³

Solubility: Soluble hauv Methanol

Pka: 2.49 ± 0.32

 

Daim ntawv thov

4-Nitrobenzyl hydrogen malonate yog ib qho tshuaj reagent siv hauv kev sib txuas ntawm (±)-thienamycin, a -Lactam tshuaj tua kab mob. Tsis tas li ntawd, nws muaj txiaj ntsig zoo rau chiral tseem ceeb nruab nrab ntawm carbapenem syntheses.

Kev npaj ntawm mono-4-nitrobenzyl malonate:

Nyob rau hauv lub nplaim taws qhuav 150 mL siab raj hauv qab argon, ntxiv 5.00 g (34.7 mmol) ntawm Meldrum's acid thiab 40 mL ntawm anhydrous MeCN.

Ntxiv 5.58 g (36.4 mmol) ntawm p-nitrobenzyl cawv rau cov kev daws teeb meem.

Kaw lub raj kom nruj thiab reflux cov tshuaj tiv thaiv ib hmos.

Concentrate cov tshuaj tiv thaiv sib tov nyob rau hauv lub siab txo.

Purify cov residue siv kem chromatography nrog 55/45 hexane / EtOAc sib tov.

Cov khoom uas tau tshwm sim yog mono-4-nitrobenzyl malonate nrog cov txiaj ntsig ntawm 87%.

 

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

 

Cov khoom raws li patent yog muab rau R & D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: 4-nitrobenzyl hydrogen malonate cas 77359-11-6, tuam ntxhab, lwm tus muag khoom, Hoobkas, yuav, hauv Tshuag

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