4- (4-Chlorophenyl) piperidin-4-ol CAS 39512-49-7

Khoom Qhia:

Khoom npe: 4- (4-Chlorophenyl) piperidin-4-ol CAS TSIS: 39512-49-7

Txhais:

4- (p-Chlorophenyl) -4-piperidinol;

4-Hydroxy-4- (4-chlorophenyl) piperidine;

4-Piperidinol, 4- (4-chlorophenyl) -;

Tshuaj& Cov Khoom Uas Lub Cev:

Tsos: Dawb rau creamy-dawb crystalline hmoov

Ntsuas: ≥99.0%

Qhov ceev: 1.216 g / cm3

Lub Ntsiab Kub: 344.5 ℃ ntawm 760 mmHg

Melting Point: 139-141 ℃

Flash Point: 162.1 ℃

Dej Solubility: 340 mg / L (20 ℃)

Qhov nqe Index: 1.6000 (kwv yees)

Qhov Ruaj: Ruaj nyob hauv qhov kub thiab txias thiab qhov siab

Cia Cia: Khaws cov thawv kaw thaum tsis siv. Muab cia rau hauv tej thawv kaw ntom. Khaws rau hauv qhov chaw txias, qhuav, thiab muaj qhov cua nyob deb ntawm cov tshuaj yeeb dej tsis haum.

Cia Lub Sij Hawm. : Tub yees

Cov Ntaub Ntawv Kev Nyab Xeeb:

HS Code: 29333999

Cov Cim Kev Nyab Xeeb: Xn, Xi

WGK Lub Teb Chaws Yelemees: 3

Cov Ntawv Ceeb Toom Uas Raug Mob: R22; R36 / 37/38

Cov Lus Qhia Kev Nyab Xeeb: S26-S37 / 39

4- (p-Chlorophenyl) -4-piperidinol yog tau los ntawm 4-chloro-α-methylstyrene ([1712-70-5]) los ntawm cyclization, salting, ntxiv, thiab hydrolysis. 1. Cyclization thiab salting 4-chloro-met-methylstyrene tau ntxiv rau qhov sib xyaw ntawm ammonium chloride thiab formaldehyde thiab muaj cov tshuaj tiv thaiv thaum txog 60 ℃ kom txog thaum cov tshuaj tiv thaiv tau pom tseeb. Tom qab ntawd ntxiv methanol, hnov ​​mob ntawm 45 ℃ rau 4h, ncu tawm methanol, ntxiv cov tshuaj muaj zog hydrochloric acid, hnov ​​mob ntawm 40-50 ℃ rau ib nrab ib teev, hnov ​​mob ntawm 95-100 ℃ rau 4h, thiab tawm thaum hmo ntuj. Ntxiv kua dej hauv paus rau pH 10-11. Kev rho tawm nrog toluene, rov qab los ntawm toluene nyob rau hauv cov txheej txheem txo qis, Chembook residual daws diluted nrog acetone, ntxiv acetic acid rau pH 7, crystallization, pom, acetone ntxuav, kom qhuav, 4-p-chlorobenzene 1,2,3, 6-tetrahydropyridine acetate. 2. Txuas ntxiv thiab hydrolysis Cov ntsev ua kua acetate tau yaj hauv glacial acetic acid, yaj hauv hydrogen bromide roj ntawm 30 ℃, crystallized tom qab saturation, thiab lim rau 4-p-chlorobenzen-4-bromopiperidine hydrobromide. Sib xyaw nrog dej, txiav txim siab nrog cov roj carbon activated ntawm 40-45 ℃, lim tawm cov roj carbon activated, nruab nrog alkali, thiab cov nplai dawb uas muaj nag lossis daus. Lub lim dej lim cov khoom lag luam yog recrystallized nrog toluene kom tau txais cov khoom tiav.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: 4- (4-chlorophenyl) piperidin-4-ol cas 39512-49-7, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: Chlorodimethylphenylsilane CAS 768-33-2
• Tom ntej: 2,6-Dibromo-4-methylpyridine CAS 73112-16-0